Prescription onlyLower-cost generic available

Zestoretic

(Lisinopril / Hydrochlorothiazide)

  • Pill
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Lowers blood pressure.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

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  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
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Side effects for Zestoretic (Lisinopril / Hydrochlorothiazide)

From clinical trials of Zestoretic / High blood pressure (tablet) ( 1137)

  • DizzinessDizziness8% for Lisinopril/Hydrochlorothiazide vs.2% for placebo
  • HeadacheHeadache5% for Lisinopril/Hydrochlorothiazide vs.2% for placebo
  • CoughCough4% for Lisinopril/Hydrochlorothiazide vs.1% for placebo
  • FatigueFatigue4% for Lisinopril/Hydrochlorothiazide vs.1% for placebo
  • Orthostatic effectsOrthostatic effects3% for Lisinopril/Hydrochlorothiazide vs.1% for placebo
  • DiarrheaDiarrhea3% for Lisinopril/Hydrochlorothiazide vs.2% for placebo
  • NauseaNausea2% for Lisinopril/Hydrochlorothiazide vs.2% for placebo
  • Upper respiratory infectionUpper respiratory infection2% for Lisinopril/Hydrochlorothiazide vs.0% for placebo
  • Muscle crampsMuscle cramps2% for Lisinopril/Hydrochlorothiazide vs.0% for placebo
  • Muscle weaknessMuscle weakness2% for Lisinopril/Hydrochlorothiazide vs.1% for placebo

What to expect when you take Zestoretic (Lisinopril / Hydrochlorothiazide)

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Tips from our pharmacists
  • Makes you urinate more often, so avoid taking it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.

Risks and Warnings for Zestoretic (Lisinopril / Hydrochlorothiazide)

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    • Higher risk if:
    • Women of childbearing age

    Zestoretic (Lisinopril / Hydrochlorothiazide) can cause birth defects or death to a fetus. If you are pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Zestoretic (Lisinopril / Hydrochlorothiazide)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Pregnancy
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • Doesn't work as well in people with severe kidney problems.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Tips from our pharmacists
  • Requires routine blood tests to check kidney function.
  • Risks from our pharmacists
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.