Prescription onlyLower-cost generic availableClass: Cardiovascular


(lisinopril / hydrochlorothiazide)

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Lowers blood pressure.

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Our bottom line

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

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  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
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  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
How it works

Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.

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Side effect rates for Zestoretic (lisinopril / hydrochlorothiazide)

1137 From clinical trials of Zestoretic / High blood pressure (tablet)
  • Dizziness
  • Headache
  • Cough
  • Fatigue
  • Orthostatic effects
  • Diarrhea
  • Nausea
  • Upper respiratory infection
  • Muscle cramps
  • Muscle weakness

Risks and Warnings for Zestoretic (lisinopril / hydrochlorothiazide)

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    • Higher risk if:
    • Women of childbearing age

    Zestoretic (Lisinopril / Hydrochlorothiazide) can cause birth defects or death to a fetus. If you are pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Zestoretic (lisinopril / hydrochlorothiazide)

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Kidneys and liver
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.