Zofran

(Ondansetron)

3.6/ 5 average rating with 366 reviewsforZofran
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Helps you feel less queasy.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.

Quick facts about Zofran
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (ondansetron)
Prices and discounts
Lowest price for 30 4mg tablets
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$13.13
  • Retail price
    $16.29
  • Savings
    19%

Upsides

  • Available in generic.
  • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
  • Starts working fast (in 30 minutes.
People’s experience with Zofran

366reviews so far. What do you think?

Downsides

  • Can cause headaches.
  • Can interact with antidepressants.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
Prices and discounts
Lowest price for 30 4mg tablets
Determining your location...
$13.13
  • Retail price
    $16.29
  • Savings
    19%
How it works

Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.

Quick facts about Zofran
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (ondansetron)

Dosage forms

  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
People’s experience with Zofran

366reviews so far. What do you think?

Skip side effects section. Skip to risks and warnings section.

Side effect rates for Zofran (Ondansetron)

From 453 clinical trials of Zofran when taken for nausea/vomiting from chemotherapy (0.45 mg/kg)
  • Headache
  • Diarrhea
  • Constipation
  • Fever
  • Increased AST and ALT

Risks and Warnings for Zofran (Ondansetron)

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  • Serotonin syndrome is a rare but potentially life-threatening condition caused when there's too much serotonin active in the brain. Your risk goes up if you use Zofran (Ondansetron) with other medications that affect serotonin (other antidepressants, lithium, medications for migraine headaches, and St. John's wort). Symptoms include fast heart rate, sweating, muscle stiffness or spasms, fever, and confusion. Go to the hospital right away if you have symptoms.

Common concerns from people taking Zofran (Ondansetron)

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Pregnancy
Interactions
  • Can interact with antidepressants.
Sleep
  • Reviewed Zofranon 10/10/2016Will make you tired
    16
    Woman
    Nausea and vomiting after surgery