Prescription onlyLower-cost generic availableClass: Gastrointestinal



Prescription onlyLower-cost generic availableClass: Gastrointestinal
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Helps you feel less queasy.

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Our bottom line

Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.

Price and discounts
Best available price for 30 (4mg) tablets of ondansetron


  • Available in generic.
  • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
  • Starts working fast (in 30 minutes.
People say this drug is:
366 reviews


  • Can cause headaches.
  • Can interact with antidepressants.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
How it works

Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.

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Side effect rates for Zofran (ondansetron)

453 From clinical trials of Zofran / Nausea/Vomiting from chemotherapy (0.45 mg/kg)
  • Headache
  • Diarrhea
  • Constipation
  • Fever
  • Increased ast and alt

Risks and Warnings for Zofran (ondansetron)

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  • Serotonin syndrome is a rare but potentially life-threatening condition caused when there's too much serotonin active in the brain. Your risk goes up if you use Zofran (Ondansetron) with other medications that affect serotonin (other antidepressants, lithium, medications for migraine headaches, and St. John's wort). Symptoms include fast heart rate, sweating, muscle stiffness or spasms, fever, and confusion. Go to the hospital right away if you have symptoms.

Common concerns from people taking Zofran (ondansetron)

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  • Can interact with antidepressants.
  • Will make you tired