Prescription onlyLower-cost generic availableClass: Gastrointestinal

Zofran Alternatives

(ondansetron)

Prescription onlyLower-cost generic availableClass: Gastrointestinal
Back to: Full Site Navigation

Compare Zofran (ondansetron) to alternatives

These medications are comparable to Zofran (ondansetron) or used for similar purposes.

Zofran
(ondansetron)

Phenergan
(promethazine)

Transderm-Scop
(scopolamine)

Compro
(prochlorperazine)

Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Helps you feel less queasy. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.Prevents nausea and vomiting. Transderm-Scop (scopolamine) is a low-hassle patch that works well to prevent nausea and vomiting, but it takes several hours to work.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.91Zofran
Reviews for Zofran
66%
of people (All ages) say Zofran is worth it
51%
say it works well
15%
say it's a big hassle
366 reviews
Have you used Zofran (ondansetron)?
Worth itNot sureNot worth it
Reviews for Phenergan
82%
-16% worse vs. Zofran
76%
-25% worse vs. Zofran
5%
-10% worse vs. Zofran
Have you used Phenergan (promethazine)?
Worth itNot sureNot worth it
Reviews for scopolamine
73%
-7% worse vs. Zofran
58%
-7% worse vs. Zofran
19%
+4% better vs. Zofran
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it
Reviews for Compro
45%
+21% better vs. Zofran
35%
+16% better vs. Zofran
35%
+20% better vs. Zofran
Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it
Side effects
ZofranPhenerganscopolamineCompro
  • Headache 2%
  • Constipation 11%
  • Fever 5%
  • Increased ast and alt 5%
  • Drowsiness 4%
  • Itching 2%
  • Tingling sensation 2%
More Zofran side effects »

The Phenergan FDA package insert doesn’t have numbers about how common side effects are.

More about Phenergan side effects »
  • Dry mouth 12%
  • Dizziness 5%
  • Drowsiness 4%
  • Agitation 2%
  • Visual changes 2%
  • Confusion 1%
  • Dilated pupils 4%
  • Sore throat 1%
More scopolamine side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
How it works
ZofranPhenerganscopolamineCompro
Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Phenergan (Promethazine) is an antihistamine, which helps control allergies. It also seems to block your body's natural reflex for vomiting, which makes it useful as an antiemetic (anti-nausea medicine).Transderm-Scop (scopolamine) is an anti-nausea medicine. It works by blocking signals in the part of your brain that causes vomiting.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
ZofranPhenerganscopolamineCompro
Prescription onlyPrescription onlyPrescription onlyPrescription only
Available as
ZofranPhenerganscopolamineCompro
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Pill
  • Liquid
  • Suppository
  • Patch
  • Pill
  • Suppository
Used for
ZofranPhenerganscopolamineCompro
Risk factors for serious side effects
ZofranPhenerganscopolamineCompro
  • Long QT syndrome
Detailed Zofran (ondansetron) risks & warnings »
  • Children under 2 years of age
  • History of seizures
  • Age over 65
Detailed Phenergan (promethazine) risks & warnings »
  • Open angle glaucoma
  • Blockages in the stomach, bowels or bladder
  • MRI examination
  • History of seizures
  • History of psychosis
Detailed Transderm-Scop (scopolamine) risks & warnings »
  • Over age 65
  • Dementia
  • Taking antipsychotics
  • History of seizures
  • Age over 65
Detailed Compro (prochlorperazine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
ZofranPhenerganscopolamineCompro
  • Can interact with antidepressants.
No interactions related info.No interactions related info.No interactions related info.
Alcohol
ZofranPhenerganscopolamineCompro
No alcohol related info.
  • Don't drink alcohol to avoid intense side effects.
No alcohol related info.
  • Don't drink alcohol to avoid intense side effects.
Pain
ZofranPhenerganscopolamineCompro
No pain related info.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
No pain related info.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
Sleep
ZofranPhenerganscopolamineCompro
No sleep related info.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
Upsides and benefits
ZofranPhenerganscopolamineCompro
  • Available in generic.
  • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
  • Starts working fast (in 30 minutes.
  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Transderm-Scop (scopolamine) is well tolerated.
  • Prevents nausea for 3 days.
  • Because Transderm-Scop (scopolamine) is a skin patch, it's a good alternative to stopping nausea and vomiting if you're not able to swallow pills.
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
Downsides and risks
ZofranPhenerganscopolamineCompro
  • Can cause headaches.
  • Can interact with antidepressants.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
  • Can only be used for prevention of nausea and vomiting. It can't stop nausea or vomiting that's already happening.
  • The side effects can be worse if you are 65 and older.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You're more likely to have heat stroke or feel dehydrated.
  • It takes a few hours for Transderm-Scop (scopolamine) to kick in, so you have to remember to take it beforehand.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
Tips from our pharmacists for people taking the medication
ZofranPhenerganscopolamineCompro
  • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
  • Can cause headache, fatigue or constipation.
  • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
  • It takes 30 minutes for Zofran to start working.
  • Promethazine comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
  • Don't give to kids 2 and under.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
  • Avoid using if you experience seizures (epilepsy).
  • Don't use if you're 65 or older because you're at higher risk for serious side effects.
  • Starts working in 6 to 8 hours.
  • Apply Transderm-Scop (scopolamine) to a clean, dry, hairless area of the skin behind the ear. Press down for 30 seconds to make sure the patch stays firmly.
  • After handling the patch, make sure to wash your hands with soap and water to avoid accidental contact with your eyes.
  • If the patch comes off, throw it away and use a new patch.
  • You can prevent skin irritation by alternating ears and washing the area of your ear that you had placed the patch on.
  • If you're using this before surgery, place it the day before, then leave it on until the day after your surgery.
  • Take the patch off before you have an MRI because it can cause the skin to burn.
  • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
  • Avoid using if you experience seizures (epilepsy).
  • Don't use if you're 65 or older because you're at higher risk for serious side effects.
Learn more
More about ZofranSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zofran (ondansetron)?
Worth itNot sureNot worth it
More about PhenerganSide effectsReviews & ratingsFDA package insert
Have you used Phenergan (promethazine)?
Worth itNot sureNot worth it
More about scopolamineSide effectsReviews & ratingsFDA package insert
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it
More about ComproSide effectsReviews & ratingsFDA package insert
Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it