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Zofran Alternatives

(Ondansetron)

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Compare Zofran (Ondansetron) to alternatives

These medications are comparable to Zofran (Ondansetron) or used for similar purposes.

Zofran
(Ondansetron)

Phenergan
(Promethazine)

Transderm-Scop
(Scopolamine)

Compro
(Prochlorperazine)

Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Helps you feel less queasy. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.Helps you feel less queasy. Transderm-Scop (Scopolamine) works well to prevent nausea and vomiting and the patch is low-hassle, but it takes about 4 hours to kick in.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.887323943661972Zofran
Reviews for Zofran (Ondansetron)
66%
of people say Zofran (Ondansetron) is worth it
50%
say it works well
15%
say it's a big hassle
Reviews for Phenergan (Promethazine)
79%
+13% vs. Zofran (Ondansetron)
73%
+23% vs. Zofran (Ondansetron)
3%
+12% vs. Zofran (Ondansetron)
Reviews for Transderm-Scop (Scopolamine)
72%
+6% vs. Zofran (Ondansetron)
56%
+6% vs. Zofran (Ondansetron)
20%
5% vs. Zofran (Ondansetron)
Reviews for Compro (Prochlorperazine)
45%
21% vs. Zofran (Ondansetron)
35%
15% vs. Zofran (Ondansetron)
35%
20% vs. Zofran (Ondansetron)
Side effects
ZofranPhenerganScopolamineCompro
  • Fever 5%
  • Drowsiness 4%
  • Headache 2%
More Zofran side effects »

The Phenergan FDA package insert doesn’t have numbers about how common side effects are.

More about Phenergan side effects »
  • Any side effect 9%
  • Drowsiness 4%
  • Visual impairment 2%
  • Agitation 2%
  • Confusion 1%
  • Sore throat 1%
More Scopolamine side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
How it works
ZofranPhenerganScopolamineCompro
Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Phenergan (Promethazine) is an antihistamine, which helps control allergies. It also seems to block your body's natural reflex for vomiting, which makes it useful as an antiemetic (anti-nausea medicine).Transderm-Scop (Scopolamine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
ZofranPhenerganScopolamineCompro
Anti-nausea
Selective 5-HT3 antagonist
Prescription only
Anti-nausea
Antihistamine
Prescription only
Anti-nausea
Anticholinergic
Prescription only
Anti-nausea, Antipsychotic
Antidopaminergic
Prescription only
Available as
ZofranPhenerganScopolamineCompro
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Pill
  • Liquid
  • Suppository
  • Patch
  • Pill
  • Suppository
Used for (click to learn more)
ZofranPhenerganScopolamineCompro
Risk factors for serious side effects
ZofranPhenerganScopolamineCompro
    • Long QT syndrome
    Detailed Zofran (Ondansetron) risks & warnings »
    Coming soon.Coming soon.Coming soon.
    Pregnancy category
    ZofranPhenerganScopolamineCompro
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
    • Don't drink alcohol to avoid intense side effects.
    • You have to avoid alcohol while on the medication.
    • Don't drink alcohol if you have to use the patch.
    • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
    • Don't drink alcohol to avoid intense side effects.
    Food
    No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
    • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    ZofranPhenerganScopolamineCompro
    • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
    • Starts working fast (in 30 minutes.
    • Available in generic.
    • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
    • Available in generic.
    • Even though there's no generic version available, it's inexpensive.
    • Placed on the skin so it can be used if you can't keep anything in your stomach.
    • Can be used for long-term control of nausea and vomiting since it's only placed on every 3 days.
    • Available in generic, so it's cheap.
    • Can be taken by mouth, as a shot, or rectally.
    • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
    Downsides and risks
    ZofranPhenerganScopolamineCompro
    • Can cause headaches.
    • Can interact with antidepressants.
    • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
    • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
    • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
    • Can make your skin more sensitive to the sun.
    • Can only be used to prevent nausea and vomiting, not to treat it if it's already happening.
    • Takes about 4 hours for it to start working.
    • You have to avoid alcohol while on the medication.
    • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
    • Can't be used by people over 65 because they can be more affected by the side effects.
    • It can make you more likely to get heatstroke.
    Tips from our pharmacists for people taking the medication
    ZofranPhenerganScopolamineCompro
    • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
    • Can cause headache, fatigue or constipation.
    • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
    • It takes 30 minutes for Zofran to start working.
    • Promethazine comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
    • Don't give to kids 2 and under.
    • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
    • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
    • Don't drink alcohol to avoid intense side effects.
    • Avoid using if you experience seizures (epilepsy).
    • Don't use if you're 65 or older because you're at higher risk for serious side effects.
    • Wash your hands after you place the patch.
    • Don't touch or rub your eyes after putting on the patch before washing your hands.
    • Can cause blurry vision and sleepiness.
    • Take the patch off if you have to do an MRI.
    • Don't drink alcohol if you have to use the patch.
    • Place it on a few hours before if you know you'll be in a place where you might get motion sickness.
    • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
    • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
    • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
    • Don't drink alcohol to avoid intense side effects.
    • Avoid using if you experience seizures (epilepsy).
    • Don't use if you're 65 or older because you're at higher risk for serious side effects.
    Learn more
    More about ZofranSide effectsReviews & ratingsAlternativesFDA package insert
    More about PhenerganSide effectsReviews & ratingsFDA package insert
    More about ScopolamineSide effectsReviews & ratingsFDA package insert
    More about ComproSide effectsReviews & ratingsFDA package insert