Zoloft

(sertraline)

3.5/ 5 average rating with 1472 reviewsforZoloft
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Improves mood and helps you relax.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

Quick facts about Zoloft
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sertraline)
Prices and discounts
Lowest price for 30 100mg tablets
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$8.70

Upsides

  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.

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What to expect from Zoloft, on one page

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People’s experience with Zoloft

1472reviews so far. What do you think?

Downsides

  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.

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What to expect from Zoloft, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 30 100mg tablets
Determining your location...
$8.70
How it works

Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It raises serotonin levels in the brain, which affects mood.

Quick facts about Zoloft
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sertraline)

Used for

Dosage forms

  • Pill
  • Liquid
People’s experience with Zoloft

1472reviews so far. What do you think?

What to expect when you take Zoloft (sertraline) for Premenstrual dysphoric disorder (luteal phase dosing)

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Side effect rates for Zoloft (sertraline)

From 1714 clinical trials of Zoloft when taken for depression (50 to 200 mg/day)
  • Nausea
  • Diarrhea
  • Dry mouth
  • Difficulty sleeping
  • Drowsiness
  • Dizziness
  • Tremor
  • Fatigue
  • More sweating
  • Constipation

Risks and Warnings for Zoloft (sertraline)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Age 24 years or younger

    Zoloft (sertraline) may raise the risk of suicidal thoughts or behavior. Watch out for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Tell your doctor right away if you experience any of these thoughts.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Zoloft (sertraline)

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Interactions
  • Interacts with lots of other medicines.
  • Reviewed Zolofton 9/10/2016May be helpful to take something to counteract the diarrhea and nausea
    20
    Woman
    Depression
Alcohol
  • Reviewed Zolofton 3/26/2017Be careful with alcohol. You get drunker much quicker, and don't remember much.
    35
    Man
    Two years or more
    Anxiety
Food
  • Reviewed Zolofton 7/12/2016Start with 37.5mgs and build up. Always take with food.
    52
    Woman
    Depression
  • Reviewed Zolofton 9/12/2016it's best taken around dinner time
    18
    Woman
    OCD
  • Reviewed Zolofton 6/26/2017Take at night to reduce dizziness. I take with food and it helps.
    25
    Woman
    A few months
    Anxiety
Pain
  • Reviewed Zolofton 7/14/2016Caused stomach pain when taken before bed..none when I take with food in the morning
    58
    Man
    Panic disorder
  • Reviewed Zolofton 5/26/2017I got good effect after 7 weeks but joint pain moved in. Intolerable by week 12. Moved on to Prozac.
    60
    Man
    A few months
    PTSD
Sex
  • Reviewed ZoloftComplete loss of libido. Became an asexual zombie, lost all emotion, apathetic, numb, ruined relationships and became type A workaholic. But, on the bright side, I ended up becoming a strait A student.
    18
    Woman
    A year or so
    Anxiety
  • Reviewed ZoloftI gained 25 pounds and it wiped out my libido- felt fat and flat and nearly destroyed my marriage due to the lack of sexual interest. Made me have uncontrollable sweating.
    36
    Woman
    A year or so
    PTSD
  • Reviewed Zolofton 7/25/2016pretty drastic effect on libido
    15
    Woman
    Depression
Sleep
  • Reviewed Zolofton 8/16/2016Made me want to sleep more, moody, felt like I am losing my mind!
    51
    Woman
    Depression
  • Reviewed Zolofton 6/11/2015The drowsiness at first wears off. My chronic constipation is more normal because of the loose stool side effect..it makes me normal. I am having alittle more trouble getting to sleep .I average 7 hrs instead of 9hrs before.
    60
    Woman
    A year or so
    Depression
  • Reviewed Zoloftsleeplesness
    66
    Man
    A couple weeks
Weight
  • Reviewed ZoloftI gained a tremendous amount of weight on this drug,almost 70lbs! It somewhat worked for 3 years and then it pooped out:-( It also gave me insomnia and brain zaps as well as diarrhea when my dose increased,but the good outweighed the bad.
    30
    Woman
    Two years or more
    I took it for post partum depression with OCD
  • Reviewed ZoloftIt causes weight gain and sexual side effects.
    18
    Man
    Two years or more
  • Reviewed Zolofton 7/15/2016that it can cause weight gain, not as bad as Paxil but still be careful if you have a tendency to gain weight.
    61
    Woman
    Depression

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