Zoloft

(Sertraline)

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4.74Zoloft

Improves mood and helps you relax.

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Our bottom line

Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.

Quick facts about Zoloft
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sertraline)
Prices and discounts
Lowest price for 30 100mg tablets
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$9.95
  • Price before coupon
    $24.87
  • Lowest price with coupon
    $9.95
    60% savings

Upsides

  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
People’s experience with Zoloft

1472reviews so far. What do you think?

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Downsides

  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Prices and discounts
Lowest price for 30 100mg tablets
Determining your location...
$9.95
  • Price before coupon
    $24.87
  • Lowest price with coupon
    $9.95
    60% savings
How it works

Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.

Quick facts about Zoloft
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sertraline)

Used for

Dosage forms

  • Pill
  • Liquid
People’s experience with Zoloft

1472reviews so far. What do you think?

Worth itNot sureNot worth it

What to expect when you take Zoloft (Sertraline) for Depression

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Side effect rates for Zoloft (Sertraline)

1714 From clinical trials of Zoloft / Major Depressive Disorder (50 to 200 mg/day)
  • Abdominal Pain
  • Anorexia
  • Dyspepsia
  • Agitation
  • Ejaculation Failure
  • Sweating Increased
  • Constipation
  • Tremor
  • Fatigue
  • Dizziness

Risks and Warnings for Zoloft (Sertraline)

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    • Higher risk if:
    • Under 24 years old

    Zoloft (Sertraline) may increase risk of suicidal thoughts and behavior in children, adolescents, and young adults up to age 24. Watch for worsening depression, suicidal thoughts or behavior, or any unusual changes in mood or behavior, especially during the first few months of treatment, or when the dose changes. Report anything concerning to a doctor immediately.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Zoloft (Sertraline)

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Pregnancy
Interactions
  • It interacts with St. John's Wort and Tryptophan.
  • May be helpful to take something to counteract the diarrhea and nausea
Alcohol
  • Be careful with alcohol. You get drunker much quicker, and don't remember much.
Food
  • Start with 37.5mgs and build up. Always take with food.
  • it's best taken around dinner time
  • Take at night to reduce dizziness. I take with food and it helps.
Pain
  • Caused stomach pain when taken before bed..none when I take with food in the morning
  • I got good effect after 7 weeks but joint pain moved in. Intolerable by week 12. Moved on to Prozac.
Sex
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Complete loss of libido. Became an asexual zombie, lost all emotion, apathetic, numb, ruined relationships and became type A workaholic. But, on the bright side, I ended up becoming a strait A student.
  • I gained 25 pounds and it wiped out my libido- felt fat and flat and nearly destroyed my marriage due to the lack of sexual interest. Made me have uncontrollable sweating.
  • pretty drastic effect on libido
Sleep
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Causes less drowsiness than other antidepressants.
  • Take in morning to avoid sleep difficulty
  • The drowsiness at first wears off. My chronic constipation is more normal because of the loose stool side effect..it makes me normal. I am having alittle more trouble getting to sleep .I average 7 hrs instead of 9hrs before.
  • sleeplesness
Weight
  • I gained a tremendous amount of weight on this drug,almost 70lbs! It somewhat worked for 3 years and then it pooped out:-( It also gave me insomnia and brain zaps as well as diarrhea when my dose increased,but the good outweighed the bad.
  • It causes weight gain and sexual side effects.
  • that it can cause weight gain, not as bad as Paxil but still be careful if you have a tendency to gain weight.