Prescription onlyLower-cost generic availableClass: Mental health



Prescription onlyLower-cost generic availableClass: Mental health
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Improves mood and helps you relax.

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Our bottom line

Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.

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Best available price for 30 (100mg) tablets of sertraline


  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
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  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
How it works

Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.

What to expect when you take Zoloft (sertraline) for Depression

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Side effect rates for Zoloft (sertraline)

1714 From clinical trials of Zoloft / Major Depressive Disorder (50 to 200 mg/day)
  • Nausea
  • Diarrhea/loose stools
  • Sleep difficulty
  • Mouth dry
  • Drowsiness
  • Dizziness
  • Tremor
  • Fatigue
  • Sweating increased
  • Constipation

Risks and Warnings for Zoloft (sertraline)

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    • Higher risk if:
    • Under 24 years old

    Zoloft (Sertraline) may increase risk of suicidal thoughts and behavior in children, adolescents, and young adults up to age 24. Watch for worsening depression, suicidal thoughts or behavior, or any unusual changes in mood or behavior, especially during the first few months of treatment, or when the dose changes. Report anything concerning to a doctor immediately.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Zoloft (sertraline)

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  • It interacts with St. John's Wort and Tryptophan.
  • May be helpful to take something to counteract the diarrhea and nausea
  • Start with 37.5mgs and build up. Always take with food.
  • it's best taken around dinner time
  • Caused stomach pain when taken before bed..none when I take with food in the morning
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • The lack of libido is the only side effect that really sucks with this medication. However, this medication changed my life and with a reduced dose, I'm not noticing this effect as much. For me, Zoloft has worked wonders!
  • Complete loss of libido. Became an asexual zombie, lost all emotion, apathetic, numb, ruined relationships and became type A workaholic. But, on the bright side, I ended up becoming a strait A student.
  • I gained 25 pounds and it wiped out my libido- felt fat and flat and nearly destroyed my marriage due to the lack of sexual interest. Made me have uncontrollable sweating.
  • Causes less drowsiness than other antidepressants.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Made me very tired at first but that wore off in a couple weeks.
  • Has to be taken same time everyday, I gained 60 pounds on this med, I was lethargic, drowsiness, insomnia. Not a good med for gad .i started out low and went up to 100mg. So I gave it a good try for a yr.
  • wont let me sleep at night. dr had to give me a sleep aide. Had some weakness at first.
  • I gained a tremendous amount of weight on this drug,almost 70lbs! It somewhat worked for 3 years and then it pooped out:-( It also gave me insomnia and brain zaps as well as diarrhea when my dose increased,but the good outweighed the bad.
  • It causes weight gain and sexual side effects.
  • that it can cause weight gain, not as bad as Paxil but still be careful if you have a tendency to gain weight.