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Zoloft Alternatives

(Sertraline)

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Compare Zoloft (Sertraline) to alternatives

These medications are comparable to Zoloft (Sertraline) or used for similar purposes.

Zoloft
(Sertraline)

Cymbalta
(Duloxetine)

Wellbutrin
(Bupropion)

Celexa
(Citalopram)

Remeron
(Mirtazapine)

Oleptro
(Trazodone)

Paxil
(Paroxetine)

Lexapro
(Escitalopram)

Prozac
(Fluoxetine)

Pristiq
(Desvenlafaxine)

Effexor
(Venlafaxine)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood. Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.690531177829099Zoloft
Reviews for Zoloft (Sertraline)
59%
of people say Zoloft (Sertraline) is worth it
40%
say it works well
15%
say it's a big hassle
Reviews for Cymbalta (Duloxetine)
59%
Same vs. Zoloft (Sertraline)
49%
+9% vs. Zoloft (Sertraline)
24%
9% vs. Zoloft (Sertraline)
Reviews for Wellbutrin (Bupropion)
58%
1% vs. Zoloft (Sertraline)
38%
2% vs. Zoloft (Sertraline)
13%
+2% vs. Zoloft (Sertraline)
Reviews for Celexa (Citalopram)
60%
+1% vs. Zoloft (Sertraline)
50%
+10% vs. Zoloft (Sertraline)
15%
Same vs. Zoloft (Sertraline)
Reviews for Remeron (Mirtazapine)
47%
12% vs. Zoloft (Sertraline)
42%
+2% vs. Zoloft (Sertraline)
26%
11% vs. Zoloft (Sertraline)
Reviews for Oleptro (Trazodone)
72%
+13% vs. Zoloft (Sertraline)
48%
+8% vs. Zoloft (Sertraline)
24%
9% vs. Zoloft (Sertraline)
Reviews for Paxil (Paroxetine)
52%
7% vs. Zoloft (Sertraline)
39%
1% vs. Zoloft (Sertraline)
23%
8% vs. Zoloft (Sertraline)
Reviews for Lexapro (Escitalopram)
59%
Same vs. Zoloft (Sertraline)
46%
+6% vs. Zoloft (Sertraline)
15%
Same vs. Zoloft (Sertraline)
Reviews for Prozac (Fluoxetine)
61%
+2% vs. Zoloft (Sertraline)
40%
Same vs. Zoloft (Sertraline)
16%
1% vs. Zoloft (Sertraline)
Reviews for Pristiq (Desvenlafaxine)
48%
11% vs. Zoloft (Sertraline)
45%
+5% vs. Zoloft (Sertraline)
25%
10% vs. Zoloft (Sertraline)
Reviews for Effexor (Venlafaxine)
61%
+2% vs. Zoloft (Sertraline)
50%
+10% vs. Zoloft (Sertraline)
22%
7% vs. Zoloft (Sertraline)
Side effects
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Tremor 13%
  • Dry mouth 10%
  • Agitation 10%
  • Constipation 9%
  • Excessive sweating 7%
  • Dizziness 6%
  • Blurred vision 5%
  • Nausea/vomiting 4%
  • Headache/migraine 4%
  • Menstrual complaints 4%
More Wellbutrin side effects »
  • Drowsiness 8%
  • Nausea 7%
  • Dry mouth 6%
  • Abnormal ejaculation 5%
  • Ejaculation disorder 5%
  • Diarrhea 3%
  • Tremor 2%
  • Sweating increased 2%
  • Fatigue 2%
  • Loss of appetite 2%
More Celexa side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 17%
  • Lower sex drive 11%
  • Diarrhea 11%
  • Sleep difficulty 11%
  • Constipation 10%
  • Decreased libido 10%
More Paxil side effects »
  • Ejaculation disorder 12%
  • Ejaculation disorder (primarily ejaculatory delay) 11%
  • Sleep difficulty 10%
  • Nausea 10%
  • Diarrhea 9%
  • Headache 7%
  • Drowsiness 6%
  • Fatigue 6%
  • Dizziness 5%
  • Lower sex drive 5%
More Lexapro side effects »
  • Rash 57%
  • Sleep difficulty 20%
  • Nausea 18%
  • Muscle weakness 12%
  • Drowsiness 10%
  • Tremor 9%
  • Dry mouth 9%
  • Lower sex drive 9%
  • Loss of appetite 7%
  • Anxiety 7%
More Prozac side effects »
  • Nausea 31%
  • Excessive sweating 17%
  • Dry mouth 16%
  • Dizziness 11%
  • Constipation 10%
  • Impotence 10%
  • Sleep difficulty 9%
  • Decreased appetite 8%
  • Drowsiness 8%
  • Fatigue 7%
More Pristiq side effects »
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Sleep difficulty 16%
  • Loss of appetite 15%
  • Sweating 14%
  • Dry mouth 13%
  • Dry mouth 11%
  • Muscle weakness 10%
More Effexor side effects »
How it works
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Norepinephrine-dopamine reuptake inhibitor
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
  • Pill
  • Liquid
  • Extended release
  • Pill
  • Extended release
  • Pill
  • Oral solution
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
  • Extended release
  • Pill
  • Extended release
Used for (click to learn more)
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Zoloft (Sertraline), here’s how much better people feel.

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

After 4 weeks using Start and Wellbutrin (Bupropion), here’s how much better people feel.

After 4 weeks using Start and Celexa (Citalopram), here’s how much better people feel.

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)

After 4 weeks using Start and Paxil (Paroxetine), here’s how much better people feel.

After 4 weeks using Start and Lexapro (Escitalopram), here’s how much better people feel.

After 4 weeks using Start and Prozac (Fluoxetine), here’s how much better people feel.

After 4 weeks using Start and Pristiq (Desvenlafaxine), here’s how much better people feel.

After 4 weeks using Start and Effexor (Venlafaxine), here’s how much better people feel.

Risk factors for serious side effects
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (Sertraline) risks & warnings »
      Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
      Pregnancy category
      ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.
      • Take with food to avoid upset stomach.
      No specific food-related info.
      • Take with food to avoid upset stomach.
      No specific food-related info.No specific food-related info.
      • Take with food to avoid upset stomach.
      • Take with food to avoid upset stomach.
      • Take in the morning with food to avoid side effects.
      No specific food-related info.
      • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      No specific sex-related info.
      • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
      • Can be taken with other antidepressants to counteract their sexual side effects.
      • There are no sexual side effects from this medication.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      No specific sex-related info.
      • Fewer sexual side effects than many other antidepressants.
      • Seek medical attention for unwanted, persistent erection.
      • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      Sleep
      • Causes less drowsiness than other antidepressants.
      No specific sleep-related info.
      • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
      No specific sleep-related info.No specific sleep-related info.
      • Commonly used in lower doses to help treat sleep problems (insomnia).
      • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
      • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
      • Comes as a generic medication and is cheaper than many other sleep aides.
      • It causes drowsiness, so it's good for people who have trouble sleeping.
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
      Weight
      No specific weight-related info.No specific weight-related info.
      • It's less likely to cause weight gain than other antidepressants.
      • Can cause minor weight gain (1 to 5 pounds).
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Good option for people who are underweight or frail, because it can help you gain weight.
      • Can increase appetite and weight.
      No specific weight-related info.
      • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
      • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
      • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
      No specific weight-related info.No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
      • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
      • Causes less drowsiness than other antidepressants.
      • Lowers relapse rates for depression.
      • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
      • Effective at relieving depression symptoms.
      • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
      • Can be taken with other antidepressants to counteract their sexual side effects.
      • Has some stimulant effects, so it can be energizing.
      • Can help with ADHD symptoms.
      • Also used to suppress appetite and help you quit smoking.
      • Causes less sleepiness compared to other antidepressants.
      • Effective at relieving some depression symptoms.
      • Starts to work more quickly than most antidepressants.
      • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
      • Good option for people who are underweight or frail, because it can help you gain weight.
      • Commonly used in lower doses to help treat sleep problems (insomnia).
      • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
      • Fewer sexual side effects than many other antidepressants.
      • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
      • Comes as a generic medication and is cheaper than many other sleep aides.
      • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
      • It causes drowsiness, so it's good for people who have trouble sleeping.
      • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
      • Causes less sleepiness than some other antidepressants.
      • Lowers relapse rates of depression.
      • Lowers relapse rates of depression and bulimia nervosa.
      • Causes less sleepiness than other antidepressants.
      • It's more energizing than other antidepressants, so it's good for people who have low energy.
      • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
      • Effective at relieving symptoms and lowering relapse rates for depression.
      • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
      • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
      • Lowers relapse rates of depression.
      Downsides and risks
      ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
      • More likely to cause diarrhea than other antidepressants.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      • Not the best option for people with high blood pressure.
      • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
      • Generally not as good as other antidepressants for people who have anxiety.
      • It's less likely to cause weight gain than other antidepressants.
      • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
      • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
      • Can cause minor weight gain (1 to 5 pounds).
      • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Not a good option for you if you have heart or liver problems.
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
      • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
      • Can harm an unborn child, so you can't take it if you're pregnant.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
      • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
      • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
      • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Not a good option for you if you have heart or liver problems.
      • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
      • More likely than other antidepressants to interact with other medications you're taking.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Similar to Effexor, without any extra benefits in clinical studies.
      • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
      • Not available in generic form, so it's more expensive.
      • Overdosing on this medication could be fatal.
      • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Not the best option for people with high blood pressure.
      Tips from our pharmacists for people taking the medication
      ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
      • It interacts with St. John's Wort and Tryptophan.
      • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
      • Take with food to avoid upset stomach.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
      • There are no sexual side effects from this medication.
      • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
      • Take with food to avoid upset stomach.
      • Can increase appetite and weight.
      • Makes you sleepy. Take at bedtime.
      • Takes 8 to 12 weeks to see full effects on mood.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Can cause temporary dry mouth and upset stomach.
      • Seek medical attention for unwanted, persistent erection.
      • Makes you sleepy. Take at bedtime.
      • The controlled-release (CR) tablet can cause less nausea than other forms.
      • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
      • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
      • Take with food to avoid upset stomach.
      • Take with food to avoid upset stomach.
      • Take in the morning with food to avoid side effects.
      • Can cause sweating and high blood pressure.
      • Takes 8 to 12 weeks to see full effects on mood.
      • Stop taking slowly to avoid withdrawal symptoms.
      • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
      • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
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