Prescription onlyLower-cost generic availableClass: Mental health

ZoloftAlternatives

(sertraline)

Prescription onlyLower-cost generic availableClass: Mental health
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Compare Zoloft (sertraline) to alternatives

These medications are comparable to Zoloft (sertraline) or used for similar purposes.

Zoloft
(sertraline)

Cymbalta
(duloxetine)

Wellbutrin
(bupropion)

Celexa
(citalopram)

Remeron
(mirtazapine)

Oleptro
(trazodone)

Paxil
(paroxetine)

Lexapro
(escitalopram)

Prozac
(fluoxetine)

Pristiq
(desvenlafaxine)

Effexor
(venlafaxine)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood. Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
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Reviews & ratings
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4.74Zoloft
Reviews for Zoloft (sertraline)
59%
of people (All ages) say Zoloft (sertraline) is worth it
41%
say it works well
15%
say it's a big hassle
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Reviews for Cymbalta (duloxetine)
58%
-1% worse vs. Zoloft (sertraline)
49%
+8% better vs. Zoloft (sertraline)
24%
-9% worse vs. Zoloft (sertraline)
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
Reviews for Wellbutrin (bupropion)
60%
+1% better vs. Zoloft (sertraline)
40%
-1% worse vs. Zoloft (sertraline)
13%
+2% better vs. Zoloft (sertraline)
1164 reviews
Have you used Wellbutrin (bupropion)?
Worth itNot sureNot worth it
Reviews for Celexa (citalopram)
61%
+2% better vs. Zoloft (sertraline)
51%
+10% better vs. Zoloft (sertraline)
16%
-1% worse vs. Zoloft (sertraline)
520 reviews
Have you used Celexa (citalopram)?
Worth itNot sureNot worth it
Reviews for Remeron (mirtazapine)
45%
-14% worse vs. Zoloft (sertraline)
39%
-2% worse vs. Zoloft (sertraline)
26%
-11% worse vs. Zoloft (sertraline)
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Reviews for Oleptro (trazodone)
73%
+14% better vs. Zoloft (sertraline)
49%
+8% better vs. Zoloft (sertraline)
24%
-9% worse vs. Zoloft (sertraline)
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Reviews for Paxil (paroxetine)
52%
-7% worse vs. Zoloft (sertraline)
39%
-2% worse vs. Zoloft (sertraline)
24%
-9% worse vs. Zoloft (sertraline)
694 reviews
Have you used Paxil (paroxetine)?
Worth itNot sureNot worth it
Reviews for Lexapro (escitalopram)
61%
+2% better vs. Zoloft (sertraline)
48%
+7% better vs. Zoloft (sertraline)
15%
Same vs. Zoloft (sertraline)
1063 reviews
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
Reviews for Prozac (fluoxetine)
62%
+3% better vs. Zoloft (sertraline)
40%
-1% worse vs. Zoloft (sertraline)
16%
-1% worse vs. Zoloft (sertraline)
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Reviews for Pristiq (desvenlafaxine)
53%
-6% worse vs. Zoloft (sertraline)
49%
+8% better vs. Zoloft (sertraline)
23%
-8% worse vs. Zoloft (sertraline)
196 reviews
Have you used Pristiq (desvenlafaxine)?
Worth itNot sureNot worth it
Reviews for Effexor (venlafaxine)
62%
+3% better vs. Zoloft (sertraline)
51%
+10% better vs. Zoloft (sertraline)
23%
-8% worse vs. Zoloft (sertraline)
577 reviews
Have you used Effexor (venlafaxine)?
Worth itNot sureNot worth it
Side effects
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
  • Nausea 10%
  • Diarrhea/loose stools 6%
  • Sleep difficulty 2%
  • Mouth dry 7%
  • Fatigue 10%
  • Dizziness 2%
  • Feeling unwell 2%
  • Indigestion 4%
  • Loss of appetite 5%
  • Lower sex drive 2%
More Zoloft side effects »
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
  • Agitation 10%
  • Dry mouth 10%
  • Headache/migraine 4%
  • Constipation 9%
  • Nausea/vomiting 4%
  • Excessive sweating 7%
  • Dizziness 6%
  • Tremor 13%
  • Sleep difficulty 3%
More Wellbutrin side effects »
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
  • Nausea 17%
  • Drowsiness 14%
  • Dry mouth 6%
  • Headache 1%
  • Muscle weakness 9%
  • Constipation 5%
  • Sleep difficulty 7%
  • Ejaculatory disturbance‡§ 13%
  • Dizziness 7%
  • Diarrhea 4%
More Paxil side effects »
  • Nausea 8%
  • Sleep difficulty 5%
  • Problems with ejaculation 9%
  • Diarrhea 3%
  • Dry mouth 1%
  • Drowsiness 4%
  • Runny nose 1%
  • Fatigue 3%
  • Dizziness 2%
  • Flu-like symptoms 1%
More Lexapro side effects »
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
  • Nausea 16%
  • Dry mouth 8%
  • Sleep difficulty 6%
  • Excessive sweating 7%
  • Dizziness 5%
  • Drowsiness 5%
  • Constipation 5%
  • Decreased appetite 6%
  • Fatigue 3%
  • Anxiety 3%
More Pristiq side effects »
  • Nausea 24%
  • Dizziness 19%
  • Sleep difficulty 10%
  • Drowsiness 14%
  • Muscle weakness 12%
  • Loss of appetite 12%
  • Nervousness 10%
  • Sweating 7%
  • Abnormality of accommodation 8%
  • Indigestion 5%
More Effexor side effects »
How it works
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin in the brain which regulates mood.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
  • Pill
  • Liquid
  • Extended release
  • Pill
  • Extended release
  • Pill
  • Oral solution
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
  • Extended release
  • Pill
  • Extended release
Used for
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
Risk factors for serious side effects
ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (sertraline) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • Stopping Cymbalta (Duloxetine) suddenly
      • History of high blood pressure
      • Taking other blood-thinning drugs
        • History of bipolar disorder
        • At risk for bipolar disorder
        Detailed Cymbalta (duloxetine) risks & warnings »
        • Age 24 years or younger
        • History of depression
        • History of bipolar disorder
        • At risk for bipolar disorder
        • Withdrawing from nicotine
        • History of seizures
        • Alcoholism
        • Eating disorder
        • Higher dose
        • Drug interactions
        • History of bipolar disorder
        • At risk for bipolar disorder
        • Current kidney problems
        • Current liver problems
          Detailed Wellbutrin (bupropion) risks & warnings »
          • Age 24 years or younger
          • Using other medications that affect serotonin
          • History of bipolar disorder
          • At risk for bipolar disorder
          • Stopping Celexa (Citalopram) suddenly
          • Higher dose
          • History of heart problems
          • History of liver problems
          • Older age
          • Taking other blood-thinning drugs
            Detailed Celexa (citalopram) risks & warnings »
            • Age 24 years or younger
            • Using other medications that affect serotonin
            • History of heart problems
            • History of liver problems
            • Higher dose
            • Alcohol
            • Taking other medicines that make you less alert
                Detailed Remeron (mirtazapine) risks & warnings »
                • Age 24 years or younger
                • History of seizures
                • Alcoholism
                • Eating disorder
                • Higher dose
                • Drug interactions
                  • Age 65 years or older
                  • Alcohol
                  • Taking other medicines that make you less alert
                  Detailed Oleptro (trazodone) risks & warnings »
                  • Age 24 years or younger
                  • Using other medications that affect serotonin
                  • Stopping Paxil (Paroxetine) suddenly
                  • Taking other blood-thinning drugs
                    • History of bipolar disorder
                    • At risk for bipolar disorder
                      Detailed Paxil (paroxetine) risks & warnings »
                      • Age 24 years or younger
                      • Using other medications that affect serotonin
                      • Stopping Lexapro (escitalopram) suddenly
                      • Taking blood thinners
                        • Bipolar disorder
                        Detailed Lexapro (escitalopram) risks & warnings »
                        • Age 24 years or younger
                        • Using other medications that affect serotonin
                        • Stopping Prozac (Fluoxetine) suddenly
                        • History of heart problems
                        • History of liver problems
                        • Drug interactions
                        • Taking other blood-thinning drugs
                          • History of bipolar disorder
                          • At risk for bipolar disorder
                          Detailed Prozac (fluoxetine) risks & warnings »
                          • Age 24 years or younger
                          • Using other medications that affect serotonin
                          • Stopping Pristiq (Desvenlafaxine) suddenly
                          • History of high blood pressure
                          • Taking other blood-thinning drugs
                            • History of bipolar disorder
                            • At risk for bipolar disorder
                            Detailed Pristiq (desvenlafaxine) risks & warnings »
                            • Age 24 years or younger
                            • Using other medications that affect serotonin
                            • Stopping Effexor (Venlafaxine) suddenly
                            • History of high blood pressure
                            • Taking other blood-thinning drugs
                              • History of bipolar disorder
                              • At risk for bipolar disorder
                              Detailed Effexor (venlafaxine) risks & warnings »
                              Pregnancy

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Interactions
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              • It interacts with St. John's Wort and Tryptophan.
                              No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                              • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
                              No interactions related info.No interactions related info.No interactions related info.
                              Alcohol
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              No alcohol related info.No alcohol related info.
                              • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
                              No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
                              Food
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              No food related info.
                              • Take with food to avoid upset stomach.
                              No food related info.
                              • Take with food to avoid upset stomach.
                              No food related info.No food related info.
                              • Take with food to avoid upset stomach.
                              No food related info.
                              • Take in the morning with food to avoid side effects.
                              No food related info.No food related info.
                              Kidneys and liver
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              No kidneys and liver related info.
                              • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
                              • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
                              • Not a good option for you if you have heart or liver problems.
                              No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
                              Pain
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              No pain related info.
                              • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
                              No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
                              Sex
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              No sex related info.No sex related info.
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              No sex related info.No sex related info.No sex related info.No sex related info.
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              No sex related info.
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              Sleep
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              • Causes less drowsiness than other antidepressants.
                              • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
                              No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
                              • It causes drowsiness, so it's good for people who have trouble sleeping.
                              No sleep related info.No sleep related info.No sleep related info.No sleep related info.
                              Weight
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              No weight related info.No weight related info.
                              • It's less likely to cause weight gain than other antidepressants.
                              • Can cause minor weight gain (1 to 5 pounds).
                              • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
                              • Can increase appetite and weight.
                              • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
                              No weight related info.
                              • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
                              • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
                              • Can cause a small weight gain of 1-5 pounds.
                              No weight related info.No weight related info.No weight related info.
                              Upsides and benefits
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
                              • Causes less drowsiness than other antidepressants.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving depression and anxiety symptoms.
                              • Lowers relapse rates for depression.
                              • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving depression symptoms.
                              • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
                              • Can be taken with other antidepressants to counteract their sexual side effects.
                              • Has some stimulant effects, so it can be energizing.
                              • Can help with ADHD symptoms.
                              • Also used to suppress appetite and help you quit smoking.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving depression and anxiety symptoms.
                              • Causes less sleepiness compared to other antidepressants.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving some depression symptoms.
                              • Starts to work more quickly than most antidepressants.
                              • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
                              • Good option for people who are underweight or frail, because it can help you gain weight.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Commonly used in lower doses to help treat sleep problems (insomnia).
                              • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
                              • Fewer sexual side effects than many other antidepressants.
                              • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
                              • Comes as a generic medication and is cheaper than many other sleep aides.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving depression and anxiety symptoms.
                              • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
                              • It causes drowsiness, so it's good for people who have trouble sleeping.
                              • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving depression and anxiety symptoms.
                              • Lowers the likelihood that your depression will come back.
                              • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
                              • Effective at relieving depression and anxiety symptoms.
                              • Lowers relapse rates of depression and bulimia nervosa.
                              • Causes less sleepiness than other antidepressants.
                              • It's more energizing than other antidepressants, so it's good for people who have low energy.
                              • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving symptoms and lowering relapse rates for depression.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Effective at relieving depression and anxiety symptoms.
                              • Lowers relapse rates of depression.
                              • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
                              • Six out of ten people who use an antidepressant for the first time find that it works for them.
                              • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
                              Downsides and risks
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              • More likely to cause diarrhea than other antidepressants.
                              • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
                              • Not the best option for people with high blood pressure.
                              • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
                              • Generally not as good as other antidepressants for people who have anxiety.
                              • It's less likely to cause weight gain than other antidepressants.
                              • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
                              • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
                              • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              • Can cause minor weight gain (1 to 5 pounds).
                              • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
                              • Not a good option for you if you have heart or liver problems.
                              • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Not as effective as other medications for depression.
                              • More sedating than other antidepressants.
                              • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
                              • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Not as effective as other medications for depression.
                              • More sedating than other antidepressants.
                              • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
                              • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
                              • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
                              • Can harm an unborn child, so you can't take it if you're pregnant.
                              • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Can cause a small weight gain of 1-5 pounds.
                              • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
                              • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
                              • More likely than other antidepressants to interact with other medications you're taking.
                              • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Similar to Effexor, without any extra benefits in clinical studies.
                              • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
                              • Not available in generic form, so it's more expensive.
                              • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                              • Not the best option for people with high blood pressure.
                              • Overdosing on this medication could be fatal.
                              • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
                              • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                              • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                              Tips from our pharmacists for people taking the medication
                              ZoloftCymbaltaWellbutrinCelexaRemeronOleptroPaxilLexaproProzacPristiqEffexor
                              • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                              • It interacts with St. John's Wort and Tryptophan.
                              • Stop taking it slowly to avoid getting withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Take with food to avoid upset stomach.
                              • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
                              • Stop taking slowly to avoid withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
                              • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                              • There are no sexual side effects from this medication.
                              • Stop taking it slowly to avoid getting withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
                              • Take with food to avoid upset stomach.
                              • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                              • Stop taking it slowly to avoid getting withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Makes you sleepy. Take at bedtime.
                              • Can increase appetite and weight.
                              • Takes 8 to 12 weeks to see full effects on mood.
                              • Stop taking slowly to avoid withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Makes you sleepy. Take at bedtime.
                              • Can cause temporary dry mouth and upset stomach.
                              • Seek medical attention for unwanted, persistent erection.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Take with food to avoid upset stomach.
                              • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                              • Stop taking it slowly to avoid getting withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • The controlled-release (CR) tablet can cause less nausea than other forms.
                              • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
                              • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
                              • Don't suddenly stop taking DRUG NAME. Talk to your doctor about how to slowly go down in your dose to avoid withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Like other SSRI medications, it could take up to 8 weeks to see the full effects of Lexapro (escitalopram).
                              • Take Lexapro (escitalopram) in the morning since it can keep you up if you take it at night.
                              • Take in the morning with food to avoid side effects.
                              • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                              • Stop taking it slowly to avoid getting withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Takes 8 to 12 weeks to see full effects on mood.
                              • Can cause sweating and high blood pressure.
                              • Stop taking slowly to avoid withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                              • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
                              • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
                              • Stop taking it slowly to avoid getting withdrawal symptoms.
                              • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                              Learn more
                              More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
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