Prescription onlyLower-cost generic available

Zyban

(Bupropion)

  • Pill
  • Extended release
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Reduces nicotine cravings.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Good for blocking the withdrawal symptoms of quitting smoking. But you need to be okay with avoiding alcohol use and possibly using nicotine replacement.

  • Can help relieve the withdrawal symptoms associated with smoking.
  • Fewer sexual side effects compared to other antidepressants. Can actually boost sex drive for some people.
  • Zyban (Bupropion) does not contain nicotine, so it is not dangerous if you continue to smoke. You can even use nicotine replacement like the patch while you are taking Zyban (Bupropion)
  • Has some stimulant effects, so it can be energizing.
  • Six out of every 10 people who use an antidepressant for the first time find that it works for them.
  • Can be stimulating, so it can cause some anxiety or insomnia in the first few days.
  • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.
  • Not a good medication for you if you drink a lot.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • If you are a heavy smoker you may also need to use nicotine replacement like the patch.

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Side effects for Zyban (Bupropion)

From clinical trials of Zyban / Smoking cessation ( 611)

  • Sleep difficultySleep difficulty31% for Zyban vs.21% for placebo
  • Dry mouthDry mouth11% for Zyban vs.5% for placebo
  • DizzinessDizziness8% for Zyban vs.7% for placebo
  • Joint painJoint pain4% for Zyban vs.3% for placebo
  • RashRash3% for Zyban vs.0% for placebo
  • ItchingItching3% for Zyban vs.0% for placebo
  • Neck painNeck pain2% for Zyban vs.0% for placebo
  • Dry skinDry skin2% for Zyban vs.0% for placebo
  • Muscle painMuscle pain2% for Zyban vs.1% for placebo
  • Increased appetiteIncreased appetite2% for Zyban vs.0% for placebo

What to expect when you take Zyban (Bupropion)

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Tips from our pharmacists
  • Start treatment at least 1 week before target quit date and continue for 7-12 weeks. Can be used with nicotine replacement therapy. Take in the morning. Notify your healthcare provider for sudden mood changes or unusual thoughts.

Risks and Warnings for Zyban (Bupropion)

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    • Higher risk if:
    • History of depression
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Withdrawing from nicotine

    Some people taking Zyban (Bupropion) for smoking cessation have reported serious psychiatric effects, such as depression and, rarely, suicidal thoughts or behavior. These effects may be worse if you're withdrawing from nicotine because depression can be symptom of nicotine withdrawal. Watch for any sudden changes in mood, thinking, or behavior, and report anything concerning to a doctor immediately.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Zyban (Bupropion)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Upsides and downsides from our pharmacists
  • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.
Sex
  • Upsides and downsides from our pharmacists
  • Fewer sexual side effects compared to other antidepressants. Can actually boost sex drive for some people.