Prescription onlyLower-cost generic available



Prescription onlyLower-cost generic available
  • Pill
  • Extended release
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Reduces nicotine cravings.

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Our bottom line

Good for blocking the withdrawal symptoms of quitting smoking. But you need to be okay with avoiding alcohol use and possibly using nicotine replacement.

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  • Can help relieve the withdrawal symptoms associated with smoking.
  • Fewer sexual side effects compared to other antidepressants. Can actually boost sex drive for some people.
  • Zyban (Bupropion) does not contain nicotine, so it is not dangerous if you continue to smoke. You can even use nicotine replacement like the patch while you are taking Zyban (Bupropion)
  • Has some stimulant effects, so it can be energizing.
  • Six out of every 10 people who use an antidepressant for the first time find that it works for them.


  • Can be stimulating, so it can cause some anxiety or insomnia in the first few days.
  • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.
  • Not a good medication for you if you drink a lot.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • If you are a heavy smoker you may also need to use nicotine replacement like the patch.
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Side effect rates for Zyban (Bupropion)

611 From clinical trials of Zyban / Smoking cessation
  • Sleep difficulty
  • Dry mouth
  • Dizziness
  • Joint pain
  • Rash
  • Itching
  • Neck pain
  • Change in taste
  • Muscle pain
  • Increased appetite

Risks and Warnings for Zyban (Bupropion)

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    • Higher risk if:
    • History of depression
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Withdrawing from nicotine

    Some people taking Zyban (Bupropion) for smoking cessation have reported serious psychiatric effects, such as depression and, rarely, suicidal thoughts or behavior. These effects may be worse if you're withdrawing from nicotine because depression can be symptom of nicotine withdrawal. Watch for any sudden changes in mood, thinking, or behavior, and report anything concerning to a doctor immediately.

Common concerns from people taking Zyban (Bupropion)

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  • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.