Prescription onlyLower-cost generic available

Zyban Alternatives

(Bupropion)

Prescription onlyLower-cost generic available
  • Pill
  • Extended release
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Compare Zyban (Bupropion) to alternatives

These medications are comparable to Zyban (Bupropion) or used for similar purposes.

Zyban
(Bupropion)

Chantix
(Varenicline)

Reduces nicotine cravings. Good for blocking the withdrawal symptoms of quitting smoking. But you need to be okay with avoiding alcohol use and possibly using nicotine replacement.Helps you quit smoking. Chantix (Varenicline) is a great way to help you quit smoking and stay off cigarettes, even though many people have nausea with it.
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Reviews & ratings
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Have you used Zyban (Bupropion)?
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Have you used Chantix (Varenicline)?
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Side effects
ZybanChantix
  • Sleep difficulty 27%
  • Dream abnormality 10%
  • Application site reactiona 8%
  • Nausea 7%
  • Dry mouth 6%
  • Constipation 6%
  • Disturbed concentration 5%
  • Dizziness 4%
  • Itching 4%
  • Loss of appetite 4%
More Zyban side effects »
  • Nausea 20%
  • Abnormal dreams 8%
  • Headache 6%
  • Passing gas 6%
  • Sleep difficulty 6%
  • Constipation 5%
  • Distorted taste 4%
  • Upper respiratory tract disorder 3%
  • Vomiting 3%
  • Abdominal pain 2%
More Chantix side effects »
How it works
ZybanChantix
Zyban (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulates mood.Chantix (Varenicline) binds to nicotine receptors in the brain, preventing actual nicotine from releasing dopamine. Lower dopamine levels cause fewer cravings and withdrawal symptoms.
Type of medication
ZybanChantix
Antidepressant
Smoking cessation
Prescription only
Smoking cessation
Partial nicotine agonist
Prescription only
Available as
ZybanChantix
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
ZybanChantix
Risk factors for serious side effects
ZybanChantix
  • History of depression
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Withdrawing from nicotine
  • Age 24 and younger
  • Those taking large doses
  • Those taking MAOIs or using a nicotine patch
        Detailed Zyban (Bupropion) risks & warnings »
        • History of depression
        • History of bipolar disorder
        • History of seizures
                Detailed Chantix (Varenicline) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Alcohol
                ZybanChantix
                • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.
                No alcohol related info.
                Food
                ZybanChantix
                No food related info.
                • When you quit smoking, your food might taste better and your breath won’t smell like smoke.
                • You should always take Chantix (Varenicline) with food and a full glass of water to reduce side effects.
                Weight
                ZybanChantix
                No weight related info.
                • Patients taking Chantix (Varenicline) can gain weight if they substitute smoking for food.
                Upsides and benefits
                ZybanChantix
                • Can help relieve the withdrawal symptoms associated with smoking.
                • Fewer sexual side effects compared to other antidepressants. Can actually boost sex drive for some people.
                • Zyban (Bupropion) does not contain nicotine, so it is not dangerous if you continue to smoke. You can even use nicotine replacement like the patch while you are taking Zyban (Bupropion)
                • Has some stimulant effects, so it can be energizing.
                • Six out of every 10 people who use an antidepressant for the first time find that it works for them.
                • 44% of people taking Chantix (Varenicline) were able to quit during their initial 12 week treatment.
                • Quitting smoking can significantly lower your risk of lung cancer, heart disease, and stroke.
                • An occasional slip-up doesn't mean you have relapsed.
                • When you quit smoking, your food might taste better and your breath won’t smell like smoke.
                • You'll save a lot of money when you stop buying cigarettes.
                Downsides and risks
                ZybanChantix
                • Can be stimulating, so it can cause some anxiety or insomnia in the first few days.
                • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.
                • Not a good medication for you if you drink a lot.
                • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                • If you are a heavy smoker you may also need to use nicotine replacement like the patch.
                • You can have withdrawal symptoms like irritability and difficulty sleeping once you stop smoking.
                • Patients taking Chantix (Varenicline) can gain weight if they substitute smoking for food.
                • Changing your daily smoking patterns and keeping yourself busy can be difficult at first.
                • Rarely, some people have had suicidal thoughts while taking Chantix (Varenicline).
                • Smoking can affect how some drugs work in your body. Once you quit, your doctor may need to adjust the doses of certain medicines you're taking.
                Tips from our pharmacists for people taking the medication
                ZybanChantix
                • Start treatment at least 1 week before target quit date and continue for 7-12 weeks. Can be used with nicotine replacement therapy. Take in the morning. Notify your healthcare provider for sudden mood changes or unusual thoughts.
                • Plan a quit date with your doctor and then start taking Chantix (Varenicline) 1 week before that date. Starting Chantix (Varenicline) before you quit helps build up the medicine in your body while you are still able to smoke a few more days.
                • Be sure to tell your doctor if you have depression or mental health problems.
                • Sign up for the easy-to-use GETQUIT Plan included in your Chantix (Varenicline) starter pack for strategies to keep you off cigarettes.
                • You should always take Chantix (Varenicline) with food and a full glass of water to reduce side effects.
                • The most common side effect is nausea, which can make you feel like you are going to throw up.
                • Quitting is hard. If you slip-up and have a cigarette, don’t give up. You can still keep taking Chantix (Varenicline).
                Learn more
                More about ZybanSide effectsAlternativesFDA package insert
                Have you used Zyban (Bupropion)?
                Worth itNot sureNot worth it
                More about ChantixSide effectsReviews & ratingsFDA package insert
                Have you used Chantix (Varenicline)?
                Worth itNot sureNot worth it