Zyban (Bupropion)

Prescription only

Chantix (Varenicline)

Prescription only
1 of 1 alternatives
Reduces nicotine cravings.

Good for blocking the withdrawal symptoms of quitting smoking. But you need to be okay with avoiding alcohol use and possibly using nicotine replacement.

Helps you quit smoking.

Chantix (Varenicline) is a great way to help you quit smoking and stay off cigarettes, even though many people have nausea with it.

  • Can help relieve the withdrawal symptoms associated with smoking.
  • Fewer sexual side effects compared to other antidepressants. Can actually boost sex drive for some people.
  • Zyban (Bupropion) does not contain nicotine, so it is not dangerous if you continue to smoke. You can even use nicotine replacement like the patch while you are taking Zyban (Bupropion)
  • Has some stimulant effects, so it can be energizing.
  • Six out of every 10 people who use an antidepressant for the first time find that it works for them.
  • 44% of people taking Chantix (Varenicline) were able to quit during their initial 12 week treatment.
  • Quitting smoking can significantly lower your risk of lung cancer, heart disease, and stroke.
  • An occasional slip-up doesn't mean you have relapsed.
  • When you quit smoking, your food might taste better and your breath won’t smell like smoke.
  • You'll save a lot of money when you stop buying cigarettes.
  • Can be stimulating, so it can cause some anxiety or insomnia in the first few days.
  • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.
  • Not a good medication for you if you drink a lot.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • If you are a heavy smoker you may also need to use nicotine replacement like the patch.
  • You can have withdrawal symptoms like irritability and difficulty sleeping once you stop smoking.
  • Patients taking Chantix (Varenicline) can gain weight if they substitute smoking for food.
  • Changing your daily smoking patterns and keeping yourself busy can be difficult at first.
  • Rarely, some people have had suicidal thoughts while taking Chantix (Varenicline).
  • Smoking can affect how some drugs work in your body. Once you quit, your doctor may need to adjust the doses of certain medicines you're taking.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
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Side effects
10possible side effects
  • Insomnia
  • Dry mouth
  • Dizziness
  • Arthralgia
  • Pruritus
  • Rash
  • Neck pain
  • Increased appetite
  • Myalgia
  • Tremor
See more detailed side effects
3possible side effects
  • Any side effect
  • Nausea
  • Abnormal dreams
See more detailed side effects
Risks and warnings
  • Psychiatric effects for quitting smoking

    History of depression

    ...and 3 more risk factors

  • Suicidal thoughts or behavior

    Age 24 and younger

  • Seizures

    Those taking large doses

  • Hypertension

    Those taking MAOIs or using a nicotine patch

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    History of depression

    ...and 1 more risk factors

  • Seizures

    History of seizures

See more detailed risks and warnings