Prescription onlyLower-cost generic available

Zyprexa

(Olanzapine)

  • Pill
  • Dissolving tablet
  • Injection
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Helps control your thoughts and mood.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.

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  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Lowers relapse rates for schizophrenia and bipolar disorder.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.

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Side effects for Zyprexa (Olanzapine)

From clinical trials of Zyprexa / Adolescent schizophrenia (13 to 17 years old) (≥ 2.5 mg per day) ( 107)

  • Relaxation or sleepinessRelaxation or sleepiness39% for Zyprexa vs.9% for placebo
  • Weight increaseWeight increase31% for Zyprexa vs.9% for placebo
  • HeadacheHeadache17% for Zyprexa vs.6% for placebo
  • Increased appetiteIncreased appetite17% for Zyprexa vs.9% for placebo
  • DizzinessDizziness8% for Zyprexa vs.3% for placebo
  • Abdominal painAbdominal pain6% for Zyprexa vs.3% for placebo
  • Pain in extremityPain in extremity6% for Zyprexa vs.3% for placebo
  • Dry mouthDry mouth4% for Zyprexa vs.0% for placebo
  • FatigueFatigue3% for Zyprexa vs.3% for placebo

What to expect when you take Zyprexa (Olanzapine) for Schizophrenia

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Tips from our pharmacists
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.

Risks and Warnings for Zyprexa (Olanzapine)

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    • Higher risk if:
    • Elderly patients with dementia

    Older patients with dementia-related psychosis have a higher risk of death when treated with antipsychotic medications. Zyprexa (Olanzapine) is not approved to treat dementia-related psychosis.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Zyprexa (Olanzapine)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Food
  • Risks from our pharmacists
  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • WEIGHT GAIN No control over appetite, craved salty and sweet food only/ Started to abuse laxatives . This was only 1.25mg dosage. Bad drug for me. And diabetes does not appeal to me.
    Age: 58
    Gender: Woman
    Taken for: Schizophrenia
  • Found it useful for treating psychosis and intrusive thoughts, also helped with anxiety & was a miracle for helping me sleep. I would take it at 6pm and be barely able to keep my eyes open by 10pm. Had brilliant sleeps off it. I stopped taking it after I gained a noticable amount of weight. I began noticing I was obsessed with food, tried to starve myself etc. Decided the psychosis would be worth enduring if it meant I didn't develop an eating disorder or obesity.
    Age: 21
    Gender: Woman
    Taken for: Bipolar I disorder (manic)
Sleep
  • Tips from our pharmacists
  • Can cause dizziness and drowsiness.
  • if satan created a drug to make people want to kill themselves this drug would be it. pure evil! it will make you want to kill yourself straight away, if that doesn't kill you the diabetes will, or a car accident, or becoming a drug addict, HOMICIDAL also side effect. if you have a job you will lose it and become homeless because you will sleep all day and can't even begin to concentrate. ask your pdoc to use seroquel or geodon before putting this toxic shit into your body!
    Age: 21
    Gender: Woman
    Taken for: Bipolar I disorder (manic)
  • Found it useful for treating psychosis and intrusive thoughts, also helped with anxiety & was a miracle for helping me sleep. I would take it at 6pm and be barely able to keep my eyes open by 10pm. Had brilliant sleeps off it. I stopped taking it after I gained a noticable amount of weight. I began noticing I was obsessed with food, tried to starve myself etc. Decided the psychosis would be worth enduring if it meant I didn't develop an eating disorder or obesity.
    Age: 21
    Gender: Woman
    Taken for: Bipolar I disorder (manic)
  • I love sleep and I found out this med makes you sleep but then I got addicted to it the withdrawals are debilitating pysical and mental
    Age: 36
    Gender: Man
    Taken for: Bipolar I disorder (manic)
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Tips from our pharmacists
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Risks from our pharmacists
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • WEIGHT GAIN No control over appetite, craved salty and sweet food only/ Started to abuse laxatives . This was only 1.25mg dosage. Bad drug for me. And diabetes does not appeal to me.
    Age: 58
    Gender: Woman
    Taken for: Schizophrenia
  • Found it useful for treating psychosis and intrusive thoughts, also helped with anxiety & was a miracle for helping me sleep. I would take it at 6pm and be barely able to keep my eyes open by 10pm. Had brilliant sleeps off it. I stopped taking it after I gained a noticable amount of weight. I began noticing I was obsessed with food, tried to starve myself etc. Decided the psychosis would be worth enduring if it meant I didn't develop an eating disorder or obesity.
    Age: 21
    Gender: Woman
    Taken for: Bipolar I disorder (manic)
  • The weight gain was not worth it. Went from 112 to 138 in less than a month
    Age: 20
    Gender: Woman
    Taken for: Depression