Prescription onlyLower-cost generic availableDrug class: Mental health

Zyprexa Alternatives

(Olanzapine)

Prescription onlyLower-cost generic availableDrug class: Mental health
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Compare Zyprexa (Olanzapine) to alternatives

These medications are comparable to Zyprexa (Olanzapine) or used for similar purposes.

Zyprexa
(Olanzapine)

Risperdal
(Risperidone)

Seroquel
(Quetiapine)

Abilify
(Aripiprazole)

Haldol
(Haloperidol)

Invega
(Paliperidone)

Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
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Reviews & ratings
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5.09Zyprexa
Reviews for Zyprexa (Olanzapine)
41%
of people (All ages) say Zyprexa (Olanzapine) is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (Olanzapine)?
Worth itNot sureNot worth it
Reviews for Risperdal (Risperidone)
42%
+1% better vs. Zyprexa (Olanzapine)
47%
-4% worse vs. Zyprexa (Olanzapine)
49%
+2% better vs. Zyprexa (Olanzapine)
Have you used Risperdal (Risperidone)?
Worth itNot sureNot worth it
Reviews for Seroquel (Quetiapine)
56%
+15% better vs. Zyprexa (Olanzapine)
50%
-1% worse vs. Zyprexa (Olanzapine)
27%
+24% better vs. Zyprexa (Olanzapine)
250 reviews
Have you used Seroquel (Quetiapine)?
Worth itNot sureNot worth it
Reviews for Abilify (Aripiprazole)
44%
+3% better vs. Zyprexa (Olanzapine)
40%
-11% worse vs. Zyprexa (Olanzapine)
34%
+17% better vs. Zyprexa (Olanzapine)
252 reviews
Have you used Abilify (Aripiprazole)?
Worth itNot sureNot worth it
Reviews for Haldol (Haloperidol)
38%
-3% worse vs. Zyprexa (Olanzapine)
42%
-9% worse vs. Zyprexa (Olanzapine)
34%
+17% better vs. Zyprexa (Olanzapine)
Have you used Haldol (Haloperidol)?
Worth itNot sureNot worth it
Reviews for Invega (Paliperidone)
29%
-12% worse vs. Zyprexa (Olanzapine)
32%
-19% worse vs. Zyprexa (Olanzapine)
35%
+16% better vs. Zyprexa (Olanzapine)
Have you used Invega (Paliperidone)?
Worth itNot sureNot worth it
Side effects
ZyprexaRisperdalSeroquelAbilifyHaldolInvega
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Positional low blood pressure 3%
  • Restlessness 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Muscle weakness 9%
  • Indigestion 6%
More Zyprexa side effects »
  • Parkinsonism 16%
  • Relaxation or sleepiness 7%
  • Restlessness 6%
  • Tremor 3%
  • Dizziness 1%
  • Nausea 3%
  • Muscle twitching 4%
  • Diarrhea 1%
  • Excessive saliva 2%
  • Vision blurred 1%
More Risperdal side effects »
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »
  • Headache 4%
  • Agitation 2%
  • Sleep difficulty 5%
  • Anxiety 4%
  • Nausea 4%
  • Restlessness 9%
  • Constipation 4%
  • Vomiting 5%
  • Dizziness 3%
  • Indigestion 2%
More Abilify side effects »

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
  • Abnormally fast heart beat 5%
  • Drowsiness 2%
  • Dizziness 1%
  • Abdominal pain upper 2%
  • Dry mouth 2%
  • Heart block 1%
  • Fatigue 1%
More Invega side effects »
How it works
ZyprexaRisperdalSeroquelAbilifyHaldolInvega
Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
ZyprexaRisperdalSeroquelAbilifyHaldolInvega
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
ZyprexaRisperdalSeroquelAbilifyHaldolInvega
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Liquid
  • Injection
  • Extended release
  • Injection
Used for
ZyprexaRisperdalSeroquelAbilifyHaldolInvega
Risk factors for serious side effects
ZyprexaRisperdalSeroquelAbilifyHaldolInvega
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Zyprexa (Olanzapine) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Risperdal (Risperidone) risks & warnings »
                  • Elderly patients with dementia
                      • History of heart problems
                      • Drug interactions
                        • People with diabetes
                        • People with high cholesterol
                        • People with diabetes
                        • Alcohol
                        • Taking other medicines that make you less alert
                          Detailed Seroquel (Quetiapine) risks & warnings »
                          • Elderly patients with dementia
                          • Age 24 years or younger
                              • History of heart problems
                              • Drug interactions
                                • People with diabetes
                                • People with high cholesterol
                                • People with diabetes
                                • Alcohol
                                • Taking other medicines that make you less alert
                                  • Phenylketonuria (PKU)
                                  Detailed Abilify (Aripiprazole) risks & warnings »
                                  • Elderly patients with dementia
                                      • History of heart problems
                                      • Drug interactions
                                        • People with diabetes
                                        • People with high cholesterol
                                        • People with diabetes
                                        • Alcohol
                                        • Taking other medicines that make you less alert
                                          Detailed Haldol (Haloperidol) risks & warnings »
                                          • Elderly patients with dementia
                                              • History of heart problems
                                              • Drug interactions
                                                • People with diabetes
                                                • People with high cholesterol
                                                • People with diabetes
                                                • Alcohol
                                                • Taking other medicines that make you less alert
                                                  Detailed Invega (Paliperidone) risks & warnings »
                                                  Pregnancy

                                                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                                  Food
                                                  ZyprexaRisperdalSeroquelAbilifyHaldolInvega
                                                  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
                                                  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
                                                  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  No food related info.
                                                  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  Sleep
                                                  ZyprexaRisperdalSeroquelAbilifyHaldolInvega
                                                  • Might make you more sleepy than some antipsychotics.
                                                  • Can cause dizziness and drowsiness.
                                                  • Can cause dizziness and drowsiness.
                                                  • Can cause dizziness, drowsiness, and low blood pressure.
                                                  No sleep related info.
                                                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                                                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                                                  Weight
                                                  ZyprexaRisperdalSeroquelAbilifyHaldolInvega
                                                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                                                  • May cause weight gain and worsen cholesterol or blood sugar.
                                                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                                                  • May cause weight gain and worsen cholesterol or blood sugar.
                                                  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
                                                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                                                  • May cause weight gain and worsen cholesterol or blood sugar.
                                                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Least likely antipsychotic to cause weight gain.
                                                  • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                                                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  • Sometimes causes weight gain and low blood pressure.
                                                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                                                  Upsides and benefits
                                                  ZyprexaRisperdalSeroquelAbilifyHaldolInvega
                                                  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
                                                  • Lowers relapse rates for schizophrenia and bipolar disorder.
                                                  • Antipsychotic medicines are all about equally effective.
                                                  • Less likely to cause heart problems than some antipsychotics.
                                                  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
                                                  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
                                                  • Antipsychotic medicines are all about equally effective.
                                                  • Less likely to cause heart problems than some antipsychotics.
                                                  • Effective at relieving psychotic symptoms and manic episodes.
                                                  • Antipsychotic medicines are all about equally effective.
                                                  • Fewer side effects than most antipsychotic medicines.
                                                  • Less likely to cause heart problems compared to some antipsychotics.
                                                  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                                                  • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
                                                  • More energizing than other antipsychotics.
                                                  • Fewer side effects than any other antipsychotics.
                                                  • Least likely antipsychotic to cause weight gain.
                                                  • Less likely to cause heart problems compared to some antipsychotics.
                                                  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
                                                  • Available as a generic, which is cheaper.
                                                  • Effective at relieving psychotic symptoms and agitation.
                                                  • Works just as well as other antipsychotic medicines.
                                                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                                                  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
                                                  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
                                                  • Works just as well as other antipsychotic medicines.
                                                  • Less likely to cause heart or liver problems than some other antipsychotic medications.
                                                  Downsides and risks
                                                  ZyprexaRisperdalSeroquelAbilifyHaldolInvega
                                                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                                                  • Might make you more sleepy than some antipsychotics.
                                                  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                                                  • You might need routine blood tests to check how the medicine is affecting your body.
                                                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                                                  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                                                  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                                                  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
                                                  • You might need routine blood tests to check how the medicine is affecting your body.
                                                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                                                  • In studies, less effective for people over age 40 for schizophrenia.
                                                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                                                  • You might need routine blood tests to check how the medicine is affecting your body.
                                                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                                                  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                                                  • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                                                  • You might need routine blood tests to check how the medicine is affecting your body.
                                                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                                                  • It's an older medicine and has a lot more side effects than newer antipsychotics.
                                                  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
                                                  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
                                                  • You might need routine blood tests to check how the medicine is affecting your body.
                                                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                                                  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
                                                  • Sometimes causes weight gain and low blood pressure.
                                                  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                                                  • You might need routine blood tests to check how the medicine is affecting your body.
                                                  • Not a good choice for elderly people who have dementia.
                                                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                                                  Tips from our pharmacists for people taking the medication
                                                  ZyprexaRisperdalSeroquelAbilifyHaldolInvega
                                                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                                                  • Can cause dizziness and drowsiness.
                                                  • For the first week, avoid activities that require you to be alert.
                                                  • May cause weight gain and worsen cholesterol or blood sugar.
                                                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                                                  • Elderly people with dementia shouldn't take it.
                                                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                                                  • Can cause dizziness and drowsiness.
                                                  • For the first week, avoid activities that require you to be alert.
                                                  • May cause weight gain and worsen cholesterol or blood sugar.
                                                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                                                  • Elderly people with dementia shouldn't take it.
                                                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                                                  • Can cause dizziness, drowsiness, and low blood pressure.
                                                  • For the first week, avoid activities that require you to be alert.
                                                  • May cause weight gain and worsen cholesterol or blood sugar.
                                                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                                                  • Elderly people with dementia shouldn't take it.
                                                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                                                  • Makes you energized. Take in the morning to avoid difficulty sleeping.
                                                  • For the first week, avoid activities that require you to be alert.
                                                  • May worsen cholesterol or blood sugar.
                                                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                                                  • Elderly people with dementia shouldn't take it.
                                                  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
                                                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                                                  • For the first week, avoid activities like driving that require you to be alert.
                                                  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
                                                  • Don't use in elderly people who have dementia.
                                                  • The oral liquid concentrate can be mixed with water or juice before taking it.
                                                  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
                                                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                                                  • For the first week, avoid activities like driving that require you to be alert.
                                                  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
                                                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                                                  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
                                                  Learn more
                                                  More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
                                                  Have you used Zyprexa (Olanzapine)?
                                                  Worth itNot sureNot worth it
                                                  More about RisperdalSide effectsReviews & ratingsFDA package insert
                                                  Have you used Risperdal (Risperidone)?
                                                  Worth itNot sureNot worth it
                                                  More about SeroquelSide effectsReviews & ratingsFDA package insert
                                                  Have you used Seroquel (Quetiapine)?
                                                  Worth itNot sureNot worth it
                                                  More about AbilifySide effectsReviews & ratingsFDA package insert
                                                  Have you used Abilify (Aripiprazole)?
                                                  Worth itNot sureNot worth it
                                                  More about HaldolSide effectsReviews & ratingsFDA package insert
                                                  Have you used Haldol (Haloperidol)?
                                                  Worth itNot sureNot worth it
                                                  More about InvegaSide effectsReviews & ratingsFDA package insert
                                                  Have you used Invega (Paliperidone)?
                                                  Worth itNot sureNot worth it