Prescription or OTCLower-cost generic available

Zyrtec D

(Cetirizine / Pseudoephedrine)

  • Extended release
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Relieves congestion and allergy symptoms.

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Prescription or OTCLower-cost generic available

Our pharmacists’ bottom line

Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.

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  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.

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Side effects for Zyrtec D (Cetirizine / Pseudoephedrine)

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These are side effects of Zyrtec D (Cetirizine / Pseudoephedrine) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you take Zyrtec D (Cetirizine / Pseudoephedrine)

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Tips from our pharmacists
  • Starts working in 30 minutes.
  • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
  • Don't cut, crush, or chew tablets; swallow them whole.
  • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.

Risks and Warnings for Zyrtec D (Cetirizine / Pseudoephedrine)

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    • Higher risk if:
    • History of high blood pressure

    Zyrtec D (Cetirizine / Pseudoephedrine) works by narrowing the blood vessels. It can cause or worsen high blood pressure. Don't use Zyrtec D (Cetirizine / Pseudoephedrine) if you have high blood pressure.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Zyrtec D (Cetirizine / Pseudoephedrine)

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The FDA category for this medication is N. It is advised that you: Unknown
Pregnancy
Kidneys & liver
  • Risks from our pharmacists
  • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
Sleep
  • Upsides and downsides from our pharmacists
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • Tips from our pharmacists
  • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
  • Risks from our pharmacists
  • People age 65 and older have a higher risk of troublesome side effects from taking antihistamine medications like Zyrtec D (Cetirizine / Pseudoephedrine). Watch out for changes in vision, severe dry mouth, trouble urinating, or constipation. Also, feelings of drowsiness may leave you "unsteady" on your feet. This can make you more likely to fall causing broken bones or other serious injuries. Talk with your doctor before using Zyrtec D (Cetirizine / Pseudoephedrine) and stop using it if you have side effects.