Prescription or OTCLower-cost generic availableClass: Respiratory

Zyrtec D 

(cetirizine / pseudoephedrine)

Prescription or OTCLower-cost generic availableClass: Respiratory
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Relieves congestion and allergy symptoms.

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Our bottom line

Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.

Price and discounts
Best available price for 60 (12 hour) tablets of cetirizine / pseudoephedrine

Upsides

  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
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Downsides

  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
How it works

Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.

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Side effect rates for Zyrtec D (cetirizine / pseudoephedrine)

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These are side effects of Zyrtec D (cetirizine / pseudoephedrine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Zyrtec D (cetirizine / pseudoephedrine)

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    • Higher risk if:
    • History of high blood pressure

    Zyrtec D (Cetirizine / Pseudoephedrine) works by narrowing the blood vessels. It can cause or worsen high blood pressure. Don't use Zyrtec D (Cetirizine / Pseudoephedrine) if you have high blood pressure.

Common concerns from people taking Zyrtec D (cetirizine / pseudoephedrine)

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Pregnancy
Kidneys and liver
  • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
Sleep
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.