Prescription or OTCLower-cost generic available

Zyrtec D

(Cetirizine / Pseudoephedrine)

Prescription or OTCLower-cost generic available
  • Extended release
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Relieves congestion and allergy symptoms.

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Our bottom line

Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.

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Upsides

  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
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Downsides

  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
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Side effect rates for Zyrtec D (Cetirizine / Pseudoephedrine)

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These are side effects of Zyrtec D (Cetirizine / Pseudoephedrine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Zyrtec D (Cetirizine / Pseudoephedrine)

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    • Higher risk if:
    • History of high blood pressure

    Zyrtec D (Cetirizine / Pseudoephedrine) works by narrowing the blood vessels. It can cause or worsen high blood pressure. Don't use Zyrtec D (Cetirizine / Pseudoephedrine) if you have high blood pressure.

Common concerns from people taking Zyrtec D (Cetirizine / Pseudoephedrine)

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Pregnancy
Kidneys and liver
  • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
Sleep
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.