Prescription or OTCLower-cost generic available

Zyrtec D Alternatives

(Cetirizine / Pseudoephedrine)

  • Extended release
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Compare Zyrtec D (Cetirizine / Pseudoephedrine) to alternatives

These medications are comparable to Zyrtec D (Cetirizine / Pseudoephedrine) or used for similar purposes.

Zyrtec D
(Cetirizine / Pseudoephedrine)

Nasacort Aq
(Triamcinolone)

Sudafed
(Pseudoephedrine)

Claritin
(Loratadine)

Claritin D
(Loratadine / Pseudoephedrine)

Flonase
(Fluticasone)

Allegra
(Fexofenadine)

Nasonex
(Mometasone)

Allegra D
(Pseudoephedrine / Fexofenadine)

Advil Allergy And Congestion Relief
(Chlorpheniramine / Ibuprofen / Phenylephrine)

Benadryl
(Diphenhydramine)

Sudafed Pe
(Phenylephrine)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Rhinocort Aqua
(Budesonide)

Zyrtec
(Cetirizine)

Relieves congestion and allergy symptoms. Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves allergy symptoms. Nasacort Aq (Triamcinolone) is the only medication in its class available over the counter for treating stuffy and runny nose due to allergies. You have to use it every day for it to work.Clears your sinuses. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.Treats allergy symptoms. Claritin (Loratadine) is a once-daily allergy relief medication that doesn't make you feel sleepy.Relieves congestion and allergy symptoms. Claritin D (Loratadine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Relieves allergy symptoms. Nasonex (Mometasone) is a good first-choice treatment for stuffy and runny noses caused by allergies.Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.Relieves cold and allergy symptoms. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves nasal allergy symptoms. Rhinocort Aqua (Budesonide) is a steroid nasal spray that works best when used regularly for your nasal allergy symptoms.Treats allergy symptoms. Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.
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Reviews & ratings
Button Group. All currently active
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5.084233261339093Zyrtec D
Reviews for Zyrtec D (Cetirizine / Pseudoephedrine)
75%
of people say Zyrtec D (Cetirizine / Pseudoephedrine) is worth it
43%
say it works well
9%
say it's a big hassle
Reviews for Nasacort Aq (Triamcinolone)
67%
8% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
39%
4% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
10%
1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Sudafed (Pseudoephedrine)
82%
+7% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
45%
+2% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
6%
+3% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Claritin (Loratadine)
74%
1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
38%
5% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
6%
+3% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Claritin D (Loratadine / Pseudoephedrine)
69%
6% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
38%
5% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
8%
+1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Flonase (Fluticasone)
72%
3% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
43%
Same vs. Zyrtec D (Cetirizine / Pseudoephedrine)
7%
+2% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Allegra (Fexofenadine)
77%
+2% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
59%
+16% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
0%
+9% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Nasonex (Mometasone)
68%
7% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
38%
5% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
8%
+1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
73%
2% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
30%
13% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
6%
+3% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Benadryl (Diphenhydramine)
85%
+10% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
57%
+14% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
8%
+1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Sudafed Pe (Phenylephrine)
44%
31% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
23%
20% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
10%
1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
+8% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
42%
1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
6%
+3% vs. Zyrtec D (Cetirizine / Pseudoephedrine)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Zyrtec (Cetirizine)
76%
+1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
46%
+3% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
7%
+2% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Side effects
Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec

We haven’t found good data for Zyrtec D side effects.

FDA side effect reports for Zyrtec D »
  • Sore throat 2%
  • Cough increased 2%
  • Tooth disorder 2%
  • Headache 2%
  • Throat pain 2%
  • Diarrhea 2%
  • Bronchitis 2%
  • Indigestion 2%
  • Flu syndrome 2%
  • Common cold 1%
More Nasacort AQ side effects »

We haven’t found good data for Sudafed side effects.

FDA side effect reports for Sudafed »

We haven’t found good data for Claritin side effects.

FDA side effect reports for Claritin »

We haven’t found good data for Claritin D side effects.

FDA side effect reports for Claritin D »
  • Asthma symptoms 4%
  • Nausea/vomiting 3%
  • Nosebleed 2%
  • Headache 1%
  • Cough 1%
  • Sore throat 1%
More Flonase side effects »
  • Vomiting 3%
  • Headache 3%
  • Cough 3%
  • Back pain 2%
  • Ear, nose, or throat infection 2%
  • Diarrhea 1%
  • Fever 1%
  • Runny nose 1%
  • Dizziness 1%
  • Stomach discomfort 1%
More Allegra side effects »
  • Nosebleed 8%
  • Headache 4%
  • Viral infection 3%
  • Menstrual cramps 2%
  • Sinus inflammation 2%
  • Musculoskeletal pain 2%
  • Sore throat 2%
  • Coughing 1%
  • Vomiting 1%
More Nasonex side effects »
  • Back pain 2%
More Allegra D side effects »

We haven’t found good data for Advil Allergy and Congestion Relief side effects.

FDA side effect reports for Advil Allergy and Congestion Relief »

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
  • Nosebleed 3%
  • Sore throat 1%
  • Bronchospasm 1%
More Rhinocort Aqua side effects »

We haven’t found good data for Zyrtec side effects.

FDA side effect reports for Zyrtec »
How it works
Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Nasacort Aq (Triamcinolone) is a nasal steroid. It works directly in your nose to help reduce swelling and inflammation from allergies.Sudafed (Pseudoephedrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Claritin (Loratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Loratadine is a low-drowsiness version.Claritin D (Loratadine / Pseudoephedrine) is a combination medicine for allergies. Loratadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Nasonex (Mometasone) is a topical steroid. It works directly where it's applied to help reduce swelling and inflammation in your nose.Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Rhinocort Aqua (Budesonide) is a steroid nasal spray that works directly in your nose to reduce swelling and allergy symptoms.Zyrtec (Cetirizine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Zyrtec is a low-drowsiness version.
Type of medication
Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
Antihistamine
2nd generation
DecongestantPrescription or OTC
Anti-inflammatory
Corticosteroid
Prescription or OTC
DecongestantPrescription or OTC
Antihistamine
2nd generation
Prescription or OTC
Antihistamine
2nd generation
DecongestantPrescription or OTC
Anti-inflammatory
Corticosteroid
Prescription or OTC
Antihistamine
2nd generation
Prescription or OTC
Anti-inflammatory
Corticosteroid
Prescription only
DecongestantAntihistamine
2nd generation
Prescription or OTC
Antihistamine
1st generation
Pain reliever
NSAID
DecongestantOver-the-counter
Antihistamine
1st generation
Prescription or OTC
DecongestantPrescription or OTC
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
CorticosteroidPrescription only
Antihistamine
2nd generation
Prescription or OTC
Available as
Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
  • Extended release
  • Nasal spray
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Chewable tablet
  • Orally disintegrating tablet
  • Liquid
  • Extended release
  • Nasal spray
  • Pill
  • Dissolving tablet
  • Liquid
  • Nasal spray
  • Extended release
  • Pill
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Pill
  • Liquid
  • Nasal spray
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
Used for (click to learn more)
Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
Risk factors for serious side effects
Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney disease
    • Current liver disease
    Detailed Zyrtec D (Cetirizine / Pseudoephedrine) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    • Don't take it with alcohol or other drugs that make you sleepy.
    No specific alcohol-related info.
    • Avoid using alcohol and other drugs that make you drowsy.
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
    Kidneys and liver
    • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    • The dose needs to be adjusted for people with kidney problems.
    No specific kidneys and liver-related info.
    • Talk to your doctor if you have high blood pressure or kidney problems before using it.
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    Sleep
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • People age 65 and older have a higher risk of troublesome side effects from taking antihistamine medications like Zyrtec D (Cetirizine / Pseudoephedrine). Watch out for changes in vision, severe dry mouth, trouble urinating, or constipation. Also, feelings of drowsiness may leave you "unsteady" on your feet. This can make you more likely to fall causing broken bones or other serious injuries. Talk with your doctor before using Zyrtec D (Cetirizine / Pseudoephedrine) and stop using it if you have side effects.
    No specific sleep-related info.
    • It can affect the quality of your sleep, so you can't take it too close to going to bed.
    • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • The antihistamine (Loratadine) in Claritin D (Loratadine / Pseudoephedrine) works as well as other antihistamines, but causes less drowsiness. It's also less sedating than Allegra D and Zyrtec D.
    • It's better to take Claritin D (Loratadine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    No specific sleep-related info.
    • Won't make you feel drowsy like some antihistamine medicines.
    No specific sleep-related info.
    • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
    • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
    • Avoid taking it close to bedtime to prevent trouble sleeping.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Shouldn't use it before you want to sleep.
    • The antihistamine (doxylamine) will help you sleep.
    • Avoid using alcohol and other drugs that make you drowsy.
    • Doesn't make you drowsy or dizzy.
    No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
    • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
    • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
    • It's available without a prescription, unlike other strong allergy medicines.
    • Available over the counter without a prescription.
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
    • Clears nasal congestion better than other decongestants like phenylephrine.
    • Can be helpful in relieving congestion-related headaches and pressure in your ears.
    • Available in regular and extended release forms.
    • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
    • Also treats hives and itchy skin.
    • Side effects are rare and usually mild.
    • Comes as a tablet, liquid, or quick-dissolving tablet.
    • Can provide quick relief of allergy symptoms for both kids and adults.
    • Okay to take with most other medications because it doesn't have many interactions.
    • Available over the counter without a prescription.
    • The antihistamine (Loratadine) in Claritin D (Loratadine / Pseudoephedrine) works as well as other antihistamines, but causes less drowsiness. It's also less sedating than Allegra D and Zyrtec D.
    • The decongestant (Pseudoephedrine) in Claritin D (Loratadine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
    • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
    • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
    • It's available without a prescription, unlike other strong allergy medicines.
    • Available as a generic medication.
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • Can be used as needed to help control symptoms in people age 13 years or older.
    • Relieves allergy symptoms, like sneezing, runny nose, and itching.
    • Approved to be used in kids and adults age 6 months and older.
    • Won't make you feel drowsy like some antihistamine medicines.
    • Available over-the-counter without a prescription.
    • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
    • It's okay to take with most other medications since it has very few interactions.
    • Available as a generic, which is cheaper.
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • Can be used as needed to help control symptoms in people age 13 years or older.
    • Available without a prescription in the drugstore.
    • It has two medications that work in different ways to help relieve nasal symptoms.
    • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
    • The decongestant (pseudoephedrine) is very good at relieving congestion.
    • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • Works to clear nasal congestion and helps you breathe better.
    • Helpful in relieving congestion-related headaches.
    • Has fewer side effects than other decongestants like pseudoephedrine.
    • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
    • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
    • The cough medicine (dextromethorphan) works well and has very few side effects.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • The antihistamine (doxylamine) will help you sleep.
    • Rhinocort Aqua (Budesonide) lowers the number of nasal symptoms you'll get during allergy season.
    • Most people don't have many side effects since it works in the nose and doesn't affect the rest of your body.
    • Doesn't make you drowsy or dizzy.
    • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
    • Works well to also treat hives and itchy skin.
    • Zyrtec (Cetirizine) is available over the counter without a prescription.
    • It comes as a tablet, liquid, and quick-dissolving tablet.
    • It's okay to take with most other medications because it has few drug interactions.
    • Most people don't get any side effects from Zyrtec (Cetirizine).
    • It can provide quick relief of allergy symptoms for both kids and adults.
    Downsides and risks
    Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • You can have more side effects when using combination pills than when using single-ingredient medications.
    • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
    • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
    • Can't be used on as-needed basis. Must be taken every day.
    • Doesn't have a counter on it, so it can be hard to remember how many sprays are left.
    • Since the medicine in Nasacort Aq (Triamcinolone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    • Needs to be primed before use and re-primed if not used for more than 2 weeks.
    • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
    • It can affect the quality of your sleep, so you can't take it too close to going to bed.
    • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
    • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
    • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
    • For some people, its effectiveness on treating allergies wears off over time.
    • Some people find that other more sedating antihistamines (like Zyrtec or Benadryl) are more effective for them.
    • Not for kids under 2 years.
    • The Reditabs version contains aspartame (phenylalanine).
    • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
    • You can have more side effects when using combination pills than when using single-ingredient medications.
    • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
    • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
    • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
    • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
    • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
    • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
    • The dose needs to be adjusted for people with kidney problems.
    • Needs to be primed 10 times before it can be used, or re-primed if not used for more than 2 weeks.
    • Doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
    • Since the medicine in Nasonex (Mometasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    • Has more side effects than Allegra since it has pseudoephedrine in it.
    • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
    • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
    • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • You shouldn't use it if you have high blood pressure.
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
    • Can make your heart race or make you feel anxious and restless.
    • Shouldn't use it before you want to sleep.
    • Not as effective after using it for 4 days in a row.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • You shouldn't use it if you have high blood pressure.
    • Needs to be used everyday to work, so it can't be used as needed.
    • Can hace an unpleasant smell or taste.
    • It's good for 120 sprays, but there isn't a counter to help you keep track of sprays.
    • Can't be used in kids younger than age 6 years.
    • Need a prescription to get Rhinocort Aqua (Budesonide).
    • Although it works fast, its effectiveness wears off for some people over time.
    • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
    • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
    • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
    Tips from our pharmacists for people taking the medication
    Zyrtec DNasacort AQSudafedClaritinClaritin DFlonaseAllegraNasonexAllegra DAdvil Allergy and Congestion ReliefBenadrylPhenylephrineNyquil Cold and FluRhinocort AquaZyrtec
    • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
    • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • Starts working in 30 minutes.
    • Don't cut, crush, or chew tablets; swallow them whole.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
    • Use Nasacort Aq (Triamcinolone) once a day, following age-specific recommendations on how many sprays to use. Don't take more than prescribed.
    • Can also cause nosebleeds, a sore throat, and headaches.
    • Blow your nose before using.
    • Can cause thrush (a fungal infection) inside the nose and throat.
    • Needs to be used regularly during allergy season for it to work. It can take 1 to 2 weeks for the medicine to start working fully.
    • Check with your doctor or pharmacist on how to use the nasal spray the right way.
    • Shake well before using it. Before the first use, prime the bottle by spraying it until you see a fine mist.
    • You need to show an ID to buy Sudafed (Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Don't take Sudafed (Pseudoephedrine) too close to bedtime since it can keep you awake.
    • Talk to your doctor if your symptoms don't get better in 1 week.
    • Starts working in 30 minutes.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • Take it only once a day.
    • Starts working in a few hours.
    • Avoid possible side effects by drinking plenty of non-caffeinated liquids.
    • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead, which might work better for you long-term.
    • Using an antihistamine eye drop might work better to help itchy or watery eyes.
    • Can make you feel sleepy, so take it at bedtime if needed.
    • You need to show an ID to buy Claritin D (Loratadine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
    • It's better to take Claritin D (Loratadine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • Starts working in 30 minutes.
    • Don't cut, crush, or chew tablets; swallow them whole.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
    • It can take several days for Flonase (Fluticasone) to start working fully.
    • Don't take more of it than was prescribed for you.
    • Blow your nose before using Flonase (Fluticasone).
    • Can also cause a headache, sore throat, or nosebleeds.
    • Can cause thrush (a fungal infection) inside the nose and throat.
    • Starts working in 1 to 2 hours depending on what dosage form you're taking.
    • Works best when taken regularly, even before symptoms are expected to appear.
    • Can make you feel dizzy or sleepy, so you can take it at bedtime.
    • Follow age-specific dosing and don't take more than recommended.
    • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
    • Use Nasonex (Mometasone) once a day, following age-specific recommendations on how many sprays to use. Don't take more than prescribed.
    • Blow your nose before using.
    • Can cause thrush (a fungal infection) inside your nose and throat. Can also cause nosebleeds, a sore throat, and headaches.
    • Needs to be used regularly during allergy season for it to work. It can take 1 to 2 weeks for the medicine to start working fully.
    • Check with your doctor or pharmacist on how to use the nasal spray the right way.
    • Shake well before using it. Before the first use, prime the bottle by spraying it until you see a fine mist.
    • It works best if you have nasal congestion and a runny nose.
    • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
    • Shouldn't be used in kids younger than 12 years old.
    • Avoid taking it close to bedtime to prevent trouble sleeping.
    • Can cause dizziness, headache, or a fast heartbeat.
    • Talk to your doctor if you have high blood pressure or kidney problems before using it.
    • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
    • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
    • Chlorpheniramine (the antihistamine ingredient in Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
    • Don't use in kids age 12 years or younger.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • Phenylephrine can make you restless, so don't take it too close to bedtime.
    • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
    • Follow age-specific dosing instructions on how much to take.
    • Starts working in 30 minutes.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Avoid using alcohol and other drugs that make you drowsy.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Works best if used everyday. It takes about one week to start seeing the best results.
    • Check with your doctor or pharmacist to make sure you know how to use this nose spray correctly.
    • Shake the spray gently and clear your nose before each use.
    • Before using it for the first time or if you haven't used it in 2 days, prime the spray pump until you see a fine mist.
    • Breathe in slowly as you're spraying and tilt your head back slightly after spraying. Wait 15 minutes before blowing your nose if needed.
    • Some people get minor nose irritation, nosebleeds, sore throat, or headaches after using it.
    • Starts working in a few hours. Only take it once a day.
    • Avoid some of the side effects by drinking plenty of non-caffeinated liquids.
    • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead since it might work better for you long-term.
    • Using an antihistamine eye drop instead can also work better to treat itchy or watery eyes.
    • Can make you feel sleepy, so take it at bedtime if needed.
    Learn more
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