Compare Abilify vs. Rexulti

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Abilify (aripiprazole)

Prescription only

Rexulti (brexpiprazole)

Prescription only
Helps control your thoughts and mood.

Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It's less likely to cause side effects than other antipsychotics.

3.2/ 5 average rating with 252 reviewsforAbilify
Helps improve your mood and control your thoughts.

Rexulti (brexpiprazole) is an option for people with depression or schizophrenia but it can be more expensive than other medicines.

Upsides
  • Effective at relieving psychotic symptoms and manic episodes.
  • More energizing than other antipsychotics.
  • Fewer side effects than other antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
  • Rexulti (brexpiprazole) does not cause as much weight gain as other similar medications.
  • Fewer side effects compared to other similar medications.
Downsides
  • Mild risk of extrapyramidal symptoms (EPS), a movement disorder that includes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find the one that works for you and that you can tolerate.
  • Avaliable only as brand name and can be more expensive than other options. However, there may be programs to help with co-pays.
  • Rexulti (brexpiprazole) can cause restlessness, especially when you take higher doses and after a long period of time.
  • Can increase your cholesterol, blood sugar, and cause weight gain.
  • Elderly patients with dementia should not take Rexulti (brexpiprazole).
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
Price
Lowest price
$2715.90
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Lowest price
$1157.45
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Reviews
252 reviews so far
44%
saidit'sworth it
40%
saiditworked well
34%
saidit'sa big hassle

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Side effects
4possible side effects
  • Restlessness
    13%
  • Sedation
    8%
  • Tremor
    6%
  • Difficulty controlling movements
    5%
See more detailed side effects
13possible side effects
  • Agitation
    9%
  • Weight gain
    7%
  • Headache
    7%
  • Sleepiness
    5%
  • Common cold
    4%
  • Tremors
    4%
  • Fatigue
    3%
  • Increased appetite
    3%
  • Dizziness
    3%
  • Anxiety
    3%
  • Restlessness
    3%
  • Constipation
    2%
  • Decreased cortisol
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
    • Age 24 years or younger
    • Use of antidepressant medications
  • Shaking and restlessness
  • Increased blood sugar and cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
    • Under 24 years of age
  • Neuroleptic malignant syndrome
  • Difficulty controlling movements
    • Women over age 65
  • Higher blood sugar and cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
  • Risk of infection
See more detailed risks and warnings