Compare Accolate vs. Flonase

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Accolate (zafirlukast)

Prescription only

Flonase (fluticasone)

Prescription or OTC
Controls asthma.

Although it's less effective than inhaled steroid medications for controlling asthma, Accolate (zafirlukast) has less side effects.

Relieves nasal allergy symptoms.

Flonase (fluticasone) is a good first-choice treatment for allergies of the nose, but long-term use can increase the risk of nosebleeds.

3.7/ 5 average rating with 890 reviewsforFlonase
Upsides
  • Can easily take as a tablet.
  • Relatively well tolerated. Serious side effects are rare.
  • Available in affordable generic form.
  • Only need to use Flonase (fluticasone) once a day. Its effects can last for up to 24 hours.
  • Available over-the-counter and cheaper than many of its alternatives.
  • Highly effective treatment of allergy symptoms in the nose.
  • Flonase (fluticasone) gives you very little to no side effects since it's a nasal spray and doesn't expose the rest of your body to the medicine.
Downsides
  • Not a first-choice medicine to control asthma.
  • People with liver problems should not take Accolate (zafirlukast).
  • Must take twice a day compared to Singulair which is only once a day.
  • Only for children 5 or older and adults.
  • You have to store Accolate (zafirlukast) in its original bottle.
  • Flonase (fluticasone) is not an appropriate medicine for people who have an injured nose or had a recent surgery in the nose.
  • Can slow down the growth rate in children.
  • Can increase the risk of bleeding and fungal infections in the nose.
  • Not recommended for those who are also taking other medicines that lower their ability to fight off infections.
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Used for
Dosage forms
  • Pill
  • Nasal spray
Price
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Reviews
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890 reviews so far
72%
saidit'sworth it
43%
saiditworked well
7%
saidit'sa big hassle

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Side effects
14possible side effects
  • Headache
    13%
  • Infection
    4%
  • Nausea
    3%
  • Diarrhea
    3%
  • Generalized pain
    2%
  • Weakness
    2%
  • Abdominal pain
    2%
  • Accidental injury
    2%
  • Dizziness
    2%
  • Muscle pain
    2%
  • Fever
    2%
  • Back pain
    2%
  • Vomiting
    2%
  • Elevated liver enzymes
    2%
See more detailed side effects
7possible side effects
  • Headache
    7%
  • Asthma-like symptoms
    7%
  • Sore throat
    6%
  • Nosebleed
    6%
  • Nausea/vomiting
    5%
  • Cough
    4%
  • Nasal burning/nasal irritation
    2%
See more detailed side effects
Risks and risk factors
  • Liver damage
    • Liver disease
  • Not for sudden asthma attack
  • Behavior changes
    • Mental health history
  • Low white blood cells
    • Tapering or discontinuing steroids
  • Increased bleeding risk
    • Antiplatelets
    • Anticoagulation
See more detailed risks and warnings
  • Decreased growth rate in children
    • Children
    • Using the medicine for a long period of time
  • Effect on wound healing
    • People who had recent surgery or injury to the nose
  • Lowered ability to fight off infections
    • People who come into contact with others who have chickenpox, measles, or tuberculosis
    • People who have not received a vaccine for chickenpox, measles, or tuberculosis
  • Damage to nose
    • Using the medicine for a long period of time
  • Sinus infection
    • People who recently had the cold or flu
  • Increased risk of nosebleeds
See more detailed risks and warnings