Compare Acetaminophen with codeine vs. Vicoprofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats mild to moderate pain.

Acetaminophen with codeine (acetaminophen / codeine) is a good option to treat pain when over-the-counter medicines aren't enough, but don't take too much acetaminophen (Tylenol) since it can hurt your liver.

3.7/ 5 average rating with 581 reviewsforAcetaminophen with codeine
Treats moderate to severe pain.

Ibudone (Hydrocodone / Ibuprofen) works well for moderate to severe pain, but it shouldn't be used long-term.

  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relief in a single pill.
  • Provides quick relief for mild to moderate pain.
  • Good for as-needed pain and control.
  • Generally well tolerated, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Effective option to relieve short-term moderate to severe pain.
  • Provides better pain control since Ibudone (Hydrocodone / Ibuprofen) is a combination medicine that works in two different ways.
  • Can cause less sleepiness than other similar medicines.
  • Available as a generic and comes in different strengths.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Many people get constipated taking Acetaminophen with codeine (acetaminophen / codeine).
  • All opioid containing medicines have the risk of addiction and withdrawal when used long-term.
  • Acetaminophen (Tylenol) has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful since many over-the-counter medicines also have acetaminophen.
  • Not used for long-term pain or for conditions like osteoarthritis or rheumatoid arthritis.
  • Can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Ibudone (Hydrocodone / Ibuprofen) any longer than your doctor recommends.
  • Ibudone (Hydrocodone / Ibuprofen) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
  • You can experience withdrawal symptoms if you suddenly stop taking Ibudone (Hydrocodone / Ibuprofen).
  • Not a good choice if you have high blood pressure or kidney, liver, or stomach problems.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
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Side effects
The Acetaminophen with codeine (acetaminophen / codeine) FDA package insert doesn’t have numbers about how common side effects are.
6possible side effects
  • Headache
  • Somnolence
  • Constipation
  • Nausea
  • Dizziness
  • Dyspepsia
See more detailed side effects
Risks and risk factors
  • Liver failure and death
    • Alcohol use
    • Taking over-the-counter medicines with acetaminophen
    • History of liver disease
  • High risk to children
  • Use with other CNS depressants
    • Use with alcohol
    • Use with benzodiazepines
    • Use with other opiates
  • Severe allergic reaction
See more detailed risks and warnings
  • Heart attack or stroke
    • History of cardiovascular disease
    • High blood pressure
    • Smoking
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 65 years or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Harm to fetus
    • Women of childbearing age
  • Low blood pressure
    • Age 65 years or older
  • Worsening kidney or liver function
    • Heart failure
    • Taking diuretics (fluid pills) or ACE inhibitors (high blood pressure/heart failure medicine)
    • Elderly people
  • Bleeding or bruising
    • Blood-thinning medicines
    • Low blood platelet count
See more detailed risks and warnings