Compare Actonel vs. Climara
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Prevents bone loss and fracture.
Actonel (risedronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.
2.9/ 5 average rating with 83 reviewsforActonel
Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.
Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.
- Actonel (risedronate) is one of the first choice medicines used for the treatment and prevention of osteoporosis.
- Available in a cheaper, generic form.
- Can take tablet form once or twice a month, once a week, or once a day.
- Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
- The patch is good for people who don't want to or can't take daily pills.
- Climara (estradiol patch) is available as a generic product, which lowers the cost.
- By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
- Lowers your risk of fractures by keeping your bones healthy.
- Need to take Actonel (risedronate) on an empty stomach first thing in the morning with a full glass of water.
- Requires the person taking this medicine to remain upright for at least 30 minutes after taking it, which can be a problem for those who have trouble sitting or standing.
- The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
- Increases your risk of uterine and breast cancer.
- If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
- Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
- If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
- Hot flashes and night sweats
- Vaginal dryness and inflammation
- Low estrogen
- Ovarian failure
- Prevention of postmenopausal osteoporosis
- Delayed-release pill
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83 reviews so far
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33possible side effects
- Back pain28%
- Joint pain24%
- Accidental injury17%
- Generalized pain14%
- Stomach pain12%
- Traumatic bone fracture12%
- Flu-like symptoms11%
- High blood pressure11%
- Urinary tract infection10%
- Sinus infection9%
- Swelling in the arms or legs8%
- Joint problems7%
- Muscle pain7%
- Stuffy or runny nose6%
- Sore throat6%
- Increased cough6%
- Neck pain5%
- Chest pain5%
- Bone pain5%
- Sleep difficulty5%
- Allergic reaction4%
16possible side effects
- Breast pain28%
- Lung infection17%
- Stomach pain16%
- Swelling of arms and legs10%
- Back pain9%
- White or yellow vaginal discharge7%
- Sore throat7%
- Stuffy nose6%
- Joint pain5%
- Sinus infection5%
Risks and risk factors
- Irritation and ulcers in the stomach and esophagus
- History of ulcers, or other stomach or esophageal problems
- History of difficulty swallowing
- Unable to sit upright or stand for 30 minutes after taking the medicine
- Pain in the bones and/or muscles
- Problems in the jawbone
- Oral or dental surgery
- Poor oral hygiene
- Leg bone fractures
- Low calcium in the blood
- History of low calcium in the blood
- Endometrial cancer
- Using estrogen for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Age 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides