Compare Actos vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos (pioglitazone)

Prescription only

Januvia (sitagliptin)

Prescription only
Lowers blood sugar.

Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.

3.1/ 5 average rating with 175 reviewsforActos
Lowers your blood sugar.

Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.

3.2/ 5 average rating with 143 reviewsforJanuvia
  • Improves sugar control and lowers A1c levels by around 1%.
  • Easily taken by mouth as a once a day pill.
  • Prevents the harmful effects of high sugar levels on your organs.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
  • May take several weeks to lower blood sugar.
  • Can cause weight gain.
  • People with heart failure or history of bladder cancer shouldn't use this medicine.
  • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
Used for
Dosage forms
  • Pill
  • Pill
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
175 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Actos (pioglitazone)?

Leave a review
143 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Januvia (sitagliptin)?

Leave a review
Side effects
11possible side effects
  • Low blood sugar
  • Swelling
  • Colds and flu
  • Headache
  • Heart failure
  • Sinus infection
  • Back pain
  • Pain in arms and legs
  • Muscle pain
  • Sore throat
  • Chest pain
See more detailed side effects
3possible side effects
  • Common cold
  • Diarrhea
  • Abdominal pain
See more detailed side effects
Risks and risk factors
  • Heart failure
    • Heart failure
  • Fluid buildup
  • Liver damage
    • Current liver problems
  • Bladder cancer
    • History of bladder cancer
  • Bone fracture
    • Women
  • Low blood sugar
See more detailed risks and warnings
  • Death from inflammation of the pancreas (pancreatitis)
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems
  • Serious allergic reactions
  • Kidney damage
    • Pre-existing kidney damage
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Severe joint pain and swelling
See more detailed risks and warnings