Compare Adcirca vs. Letairis

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Adcirca (tadalafil)

Prescription only

Letairis (ambrisentan)

Prescription only
Improves breathing in pulmonary arterial hypertension.

Adcirca (tadalafil) is very effective at treating increased pressure in the lungs. however, it commonly causes low blood pressure and headache.

Treats high blood pressure in your lungs.

Letairis (ambrisentan) is a good choice for some stages of pulmonary arterial hypertension and can help relieve your symptoms, but it won't cure you.

  • Adcirca (tadalafil) is an effective medication for treating increased pressure in the lungs.
  • It is usually taken once daily as an oral pill, compared to alternatives which are taken more frequently.
  • Is approved for all severities of pulmonary arterial hypertension.
  • Take Letairis (ambrisentan) only once a day.
  • Can help improve your quality of life and exercise ability.
  • You can use this medication even if you have kidney or liver problems.
  • Adcirca (tadalafil) is only available as brand name, so it can be expensive.
  • If you're older than age 65, you might have more side effects.
  • Can't use Adcirca (tadalafil) if you've recently taken nitrates like Isordil, Imdur, or nitroglycerin (Nitro-BID, Nitro-Dur, Nitrostat).
  • People with liver and kidney disease may be at higher risk for side effects.
  • You need to be on 2 kinds of birth control during and one month after you stop taking Letairis (ambrisentan).
  • If you're female, you have to obtain this medication through a specific program, and only certified pharmacies can dispense it.
  • Since this medication is only available as a brand, it is very expensive.
  • Can cause swelling of the arms and legs.
  • Can lower your blood counts, so you might have to get regular blood tests when you're starting Letairis (ambrisentan).
Used for
  • Pulmonary arterial hypertension
Dosage forms
  • Pill
  • Pill
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Side effects
9possible side effects
  • Headache
  • Back pain
  • Indigestion
  • Nausea
  • Muscle pain
  • Respiratory tract infection
  • Flushing
  • Pain in arms and legs
  • Common cold
See more detailed side effects
4possible side effects
  • Swelling in arms and legs
  • Stuffy nose
  • Flushing
  • Sinus infection
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Risks and risk factors
  • Heart disease
  • Prolonged erection
  • Vision changes
  • Low blood pressure
    • Taking alpha blockers
    • Taking medications for high blood pressure
    • Drinking alcohol
  • Hearing loss
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  • Danger to unborn baby
  • Fluid buildup
    • Taking Letairis (ambrisentan) with tadalafil
  • Low sperm production
  • Low blood counts
See more detailed risks and warnings