Compare Adlyxin vs. Trulicity

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Adlyxin (lixisenatide)

Prescription only

Trulicity (dulaglutide)

Prescription only
Lowers blood sugar.

Adlyxin (lixisenatide) can lower blood sugar in addition to metformin, but it must be injected and usually causes upset stomach.

Lowers your blood sugar.

Trulicity (dulaglutide) is a once-weekly injectable medicine that's used to control diabetes, but it can be expensive.

Upsides
  • Lowers A1c (average blood sugar over time) up to 1%.
  • Not as likely to cause very low blood sugar as glyburide or insulin.
  • Adlyxin (lixisenatide) is injected once daily.
  • Adlyxin (lixisenatide) comes as a pre-filled injectable pen that does not require you to measure the dose, so you may find this more convenient than other types of injections.
  • Lowers A1c (average blood sugar over time) up to 1.5%.
  • May help with weight loss and controling appetite.
  • No limitation for people with kidney problems, but close monitoring is recommended.
  • Dosed once a week compared to other injectables that have to be done daily.
  • Medicine is ready to use, without need to mix.
Downsides
  • Not good enough by itself if you have really high blood sugars. It needs to be combined with other oral anti-diabetic medicines or insulin.
  • Commonly causes upset stomach.
  • Can affect how well your birth control pills work. Take 1 hour before or 11 hours after injecting Adlyxin (lixisenatide).
  • Oral diabetes medicines work just as well and are cheaper.
  • Only available as an injection.
  • Brand name medicine and can be expensive.
  • Many people taking Trulicity (dulaglutide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
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Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
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Side effects
10possible side effects
  • Stomach discomfort
    40%
  • Nausea
    25%
  • Vomiting
    10%
  • Headache
    9%
  • Diarrhea
    8%
  • Dizziness
    7%
  • Injection site reaction
    4%
  • Upset stomach
    3%
  • Constipation
    3%
  • Signs of low blood sugar
    2%
See more detailed side effects
10possible side effects
  • Low blood sugar
    35%
  • Nausea
    21%
  • Diarrhea
    13%
  • Vomiting
    13%
  • Stomach pain
    9%
  • Low appetite
    9%
  • Indigestion
    6%
  • Tiredness
    6%
  • Constipation
    4%
  • Acid reflux
    2%
See more detailed side effects
Risks and risk factors
  • Loss of effectiveness
  • Inflammation of pancreas (pancreatitis)
    • History of pancreatitis
    • History of gallstones
    • alcoholism
    • Elevated triglycerides
  • Severe allergic reactions
  • Kidney damage
    • Several renal impairment
    • End-stage renal disease
    • Kidney problems
    • dehydration
  • Low blood sugar (hypoglycemia)
    • Use of insulin(s)
    • Use of insulin-secreting medicines
  • Overexposure to other drugs
    • Severe gastrointestinal disease
    • Gastroparesis
See more detailed risks and warnings
  • Thyroid cancer
    • History of MTC
    • History of MEN 2
  • inflammation of pancreas (pancreatitis)
    • History of pancreatitis
    • History of gallstones
    • alcoholism
    • Elevated triglycerides
  • Severe allergic reactions
  • Kidney damage
    • Kidney problems
    • dehydration
  • Low blood sugar (hypoglycemia)
    • Use of insulin(s)
    • Use of insulin-secreting medicines.
  • Severe stomach problems
    • Stomach or digestive tract disease
    • Gastroparesis
See more detailed risks and warnings