Compare Aldactazide vs. spironolactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood pressure and removes extra water from your body.

Aldactazide (spironolactone / hydrochlorothiazide) removes extra fluid from your body and lowers your blood pressure, but can cause dangerously high potassium levels.

Removes extra water from your body.

Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.

  • Lowers the risk of heart attack and stroke in people with high blood pressure.
  • Good combination pill if you have both high blood pressure and heart failure or liver failure.
  • Prevents further heart remodeling in heart failure, which lowers your risk of death.
  • Helpful for people who tend to accumulate fluid in their arms, legs, or stomach.
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
  • Can increase the risk of tumor growth with long term use.
  • Regular blood tests are needed to monitor your electrolytes and kidney function, and more frequently if you have liver or kidney disease.
  • Can make you more sensitive to sunlight.
  • May cause a reaction if you have a sulfa allergy.
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
Used for
Dosage forms
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Side effects
The Aldactazide (spironolactone / hydrochlorothiazide) FDA package insert doesn’t have numbers about how common side effects are.
The Aldactone (spironolactone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Tumor development
    • Longer use with Aldactazide (spironolactone / hydrochlorothiazide)
  • Electrolyte abnormalities
    • Kidney problems
    • Medicine that affects electrolytes
    • Diabetes
    • Liver problems
  • Severe allergic reactions
    • History of sulfa allergy
  • Gout
    • History of gout
    • Kidney problems
  • Dangerously high potassium
  • Breast pain or swelling
    • Larger doses of Aldactazide (spironolactone / hydrochlorothiazide)
    • Taking Aldactazide (spironolactone / hydrochlorothiazide) for a long time
See more detailed risks and warnings
  • Tumor development
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
  • Heart problems from high potassium
    • Current kidney problems
    • Taking other medicines that increase potassium
    • Use of salt substitutes
  • Breast pain or swelling
See more detailed risks and warnings