Compare Allopurinol vs. Benemid
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
Benemid (probenecid) can be used to lower high uric acid levels in people with gout, but it is not a first-choice treatment because it takes a long time to kick in.
- Zyloprim (allopurinol) works well to lower uric acid in the body.
- It is available as a generic medication.
- Benemid (probenecid) is available in generic.
- It can raise levels of certain antibiotics in the body and make those antibiotics work better.
- It is recommended as a second-choice medicine to help lower uric acid levels if they're not going down fast enough.
- Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
- It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
- Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
- Benemid (probenecid) is not a first-choice treatment for gout because it takes a while to kick in.
- It doesn't work well in people who are using aspirin, or have kidney problems.
- You have to take Benemid (probenecid) 2 times a day. Other stronger drugs for gout are only taken 1 time a day.
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- More gout attacks
- Kidney stones
- History of kidney stones
- Skin rash
- Liver disease
- Sleepiness or dizziness
- Taking other medications that also cause sleepiness
- Recreational drug use
- Excessive alcohol use
- Kidney stones
- Blood disorders
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Gout attacks
- Taking Benemid (probenecid) for the first few weeks
- Kidney problems
- History of kidney problems
- Stomach ulcers
- History of esophagus or stomach problems, including ulcers