Compare Allopurinol vs. Uloric

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zyloprim (allopurinol)

Prescription only

Uloric (febuxostat)

Prescription only
Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

3.7/ 5 average rating with 21 reviewsforAllopurinol
Stops gout attacks.

Uloric (febuxostat) is a medication you take once daily for gout, but it takes a few weeks to kick in.

Upsides
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
  • Uloric (febuxostat) can be used to lower uric acid if Zyloprim (allopurinol) doesn't work.
  • You only need to take Uloric (febuxostat) once a day.
  • People with mild to moderate kidney disease can use Uloric (febuxostat).
Downsides
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
  • You can have more gout attacks in the first few weeks of taking Uloric (febuxostat).
  • While taking Uloric (febuxostat), you need to drink a lot of fluids to stop kidney stones from forming.
  • You'll have to get your blood checked often with Uloric (febuxostat) therapy.
  • Uloric (febuxostat) doesn't come in generic, so it can be more expensive.
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Used for
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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Reviews
21 reviews so far
71%
saidit'sworth it
52%
saiditworked well
5%
saidit'sa big hassle

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Side effects
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
The Uloric (febuxostat) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • More gout attacks
  • Kidney stones
    • History of kidney stones
  • Skin rash
  • Liver disease
  • Sleepiness or dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
See more detailed risks and warnings
  • Gout flare-ups
  • Blood clots
    • History of stroke or heart attack
  • Liver problems
  • Allergic reaction
    • History of skin reaction to allopurinol
See more detailed risks and warnings