Compare Allopurinol vs. Uloric
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
Uloric (febuxostat) is a medication you take once daily for gout, but it takes a few weeks to kick in.
- Zyloprim (allopurinol) works well to lower uric acid in the body.
- It is available as a generic medication.
- Uloric (febuxostat) can be used to lower uric acid if Zyloprim (allopurinol) doesn't work.
- You only need to take Uloric (febuxostat) once a day.
- People with mild to moderate kidney disease can use Uloric (febuxostat).
- Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
- It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
- Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
- You can have more gout attacks in the first few weeks of taking Uloric (febuxostat).
- While taking Uloric (febuxostat), you need to drink a lot of fluids to stop kidney stones from forming.
- You'll have to get your blood checked often with Uloric (febuxostat) therapy.
- Uloric (febuxostat) doesn't come in generic, so it can be more expensive.
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- More gout attacks
- Kidney stones
- History of kidney stones
- Skin rash
- Liver disease
- Sleepiness or dizziness
- Taking other medications that also cause sleepiness
- Recreational drug use
- Excessive alcohol use
- Gout flare-ups
- Blood clots
- History of stroke or heart attack
- Liver problems
- Allergic reaction
- History of skin reaction to allopurinol