Compare Aloxi vs. granisetron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Aloxi (palonosetron)

Prescription only

granisetron

Prescription only
Stops nausea caused by chemotherapy or surgery.

Aloxi (palonosetron) is given one time to effectively reduce nausea from chemotherapy or surgery. In some cases, it will only help for a short period of time.

Helps prevent nausea and vomiting due to chemotherapy or radiation treatment

granisetron is a safe and effective medication used for preventing nausea and vomiting due to chemotherapy and radiation, but it can be very expensive.

Upsides
  • Aloxi (palonosetron) can be given through the same IV line as your chemotherapy - as a one-time dose 30 minutes before treatment starts.
  • Starts working in 30 minutes.
  • Aloxi (palonosetron) can be used in children as young as 1 month of age.
  • granisetron is effective even for those who are using chemotherapy that is associated with a high risk for causing nausea and vomiting.
  • Safe and effective option for older people, unlike some other alternatives.
  • You only need to take granisetron on the days you actually receive chemotherapy and radiation.
  • A patch form of the medication is available for those who don't want to or who are unable to take pills.
  • Safe to use for people with kidney problems.
Downsides
  • If your chemotherapy is very likely to make you feel queasy or if you have nausea after surgery, Aloxi (palonosetron) is usually only helpful for one day.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
  • granisetron only prevents symptoms of nausea and vomiting so you must take the medication before you get chemotherapy or radiation treatment.
  • Can affect the natural rhythm of your heart, especially if you take other medications that can also potentially cause the same problem.
  • Might not be a good option for those who are on certain antidepressants.
  • granisetron is very expensive compared to similar alternatives.
  • Very likely to cause side effects like headache and constipation.
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Used for
  • Nausea and vomiting from chemotherapy or surgery
  • Prevention of chemotherapy-associated nausea and vomiting
  • Prevention of radiation-associated nausea and vomiting
  • Prevention of post-surgery nausea and vomiting
Dosage forms
  • Injection
  • Pill
Price
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Reviews
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Side effects
4possible side effects
  • Abnormal heartbeat
    5%
  • Slow heart rate
    4%
  • Headache
    3%
  • Constipation
    2%
See more detailed side effects
6possible side effects
  • Headache
    20%
  • Weakness
    18%
  • Constipation
    14%
  • Diarrhea
    9%
  • Indigestion
    6%
  • Stomach pain
    4%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, some migraine medications, and St. John's wort.
  • Severe allergic reaction
See more detailed risks and warnings
  • Serotonin syndrome
    • Taking other medications that also affect serotonin levels in the brain
  • Effects on heart
    • History of arrhythmias
    • Taking other medications that can also cause irregular heartbeat
    • Electrolyte imbalance
  • Constipation
    • History of constipation problems
    • Those who had recent abdominal surgery
See more detailed risks and warnings