Compare Aloxi vs. Reglan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Aloxi (palonosetron)

Prescription only

Reglan (metoclopramide)

Prescription only
Stops nausea caused by chemotherapy or surgery.

Aloxi (palonosetron) is given one time to effectively reduce nausea from chemotherapy or surgery. In some cases, it will only help for a short period of time.

Relieves nausea and vomiting.

Reglan (metoclopramide) can stimulate your gut and relieve nausea, but it can only be used for a short period of time due to avoid serious side-effects.

Upsides
  • Aloxi (palonosetron) can be given through the same IV line as your chemotherapy - as a one-time dose 30 minutes before treatment starts.
  • Starts working in 30 minutes.
  • Aloxi (palonosetron) can be used in children as young as 1 month of age.
  • Especially useful for relieving nausea caused by cancer chemotherapy.
  • Available in an affordable, generic version
  • If tablets are hard for you to swallow, Reglan (metoclopramide) is also available in as an orally disintegrating tablet or liquid form.
Downsides
  • If your chemotherapy is very likely to make you feel queasy or if you have nausea after surgery, Aloxi (palonosetron) is usually only helpful for one day.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
  • Use for more than 12 weeks can cause involuntary movements of the eyes, tongue, face, arm, or legs.
  • May take a while to relieve nausea and vomiting caused by delayed gastric emptying.
  • Not a good option if you have Parkinson's disease, history of seizures, or blockage in your gut.
  • You may need a lower dose if you have kidney problems.
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Used for
  • Nausea and vomiting from chemotherapy or surgery
  • Diabetic gastroparesis
  • Gastroesophegeal reflux
  • Prevention of nausea and vomiting associated with chemotherapy
  • Prevention of postoperative nausea and vomiting
  • Radiological exam
  • Small bowel intubation
  • Gastric bezoars
  • Hiccups
  • Acute migraine
  • Treatment of nausea and vomiting in advanced cancer
  • Prevention of radiation therapy-induced nausea and vomiting
Dosage forms
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
  • Injectable
Price
No pricing information available
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Reviews
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Side effects
4possible side effects
  • Abnormal heartbeat
    5%
  • Slow heart rate
    4%
  • Headache
    3%
  • Constipation
    2%
See more detailed side effects
4possible side effects
  • Restlessness
    10%
  • Drowsiness
    10%
  • Fatigue
    10%
  • Lack of energy
    10%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, some migraine medications, and St. John's wort.
  • Severe allergic reaction
See more detailed risks and warnings
  • Late, irreversible, involuntary movements (tardive dyskinesia)
    • Elderly
    • Women
    • Diabetics
  • Depression
    • Depression
  • Neuroleptic malignant syndrome
  • Early, reversible involuntary movements (extrapyramidal side-effects)
    • Younger than 30 years old
    • High doses of Reglan (metoclopramide)
    • Children and teens
See more detailed risks and warnings