Compare Aloxi vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Aloxi (palonosetron)

Prescription only

Zyprexa (olanzapine)

Prescription only
Stops nausea caused by chemotherapy or surgery.

Aloxi (palonosetron) is given one time to effectively reduce nausea from chemotherapy or surgery. In some cases, it will only help for a short period of time.

Helps control your thoughts and mood.

Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.

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3.7/ 5 average rating with 68 reviewsforZyprexa
Upsides
  • Aloxi (palonosetron) can be given through the same IV line as your chemotherapy - as a one-time dose 30 minutes before treatment starts.
  • Starts working in 30 minutes.
  • Aloxi (palonosetron) can be used in children as young as 1 month of age.
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
Downsides
  • If your chemotherapy is very likely to make you feel queasy or if you have nausea after surgery, Aloxi (palonosetron) is usually only helpful for one day.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
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Used for
  • Nausea and vomiting from chemotherapy or surgery
Dosage forms
  • Injection
  • Pill
  • Dissolving tablet
  • Injection
Price
Lowest price
$21.31
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Lowest price
$490.88
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Reviews
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68 reviews so far
41%
saidit'sworth it
51%
saiditworked well
51%
saidit'sa big hassle

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Side effects
4possible side effects
  • Abnormal heartbeat
    5%
  • Slow heart rate
    4%
  • Headache
    3%
  • Constipation
    2%
See more detailed side effects
9possible side effects
  • Drowsiness
    48%
  • Weight gain
    28%
  • Increased appetite
    28%
  • Headache
    17%
  • Fatigue
    14%
  • Dizziness
    7%
  • Dry Mouth
    7%
  • Abdominal pain
    6%
  • Pain in extremity
    5%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, some migraine medications, and St. John's wort.
  • Severe allergic reaction
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Blood disorders
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar, high cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings
Learn more about Aloxi (palonosetron)
Learn more about Zyprexa (olanzapine)