Compare Amaryl vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Amaryl (glimepiride)

Prescription only

Byetta (Exenatide)

Prescription only
Lowers blood sugar.

Amaryl (glimepiride) is an effective medicine for lowering blood sugar, but it can cause weight gain.

Lowers blood sugar.

Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.

Upsides
  • Needs to be taken only once a day.
  • Effectively lowers blood sugar and A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Amaryl (glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Available as a generic form and is relatively cheap.
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
Downsides
  • Amaryl (glimepiride) might cause weight gain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Not preferred for people age 65 or older because they are at higher risk of experiencing side effects such as low blood sugar.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
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Used for
Dosage forms
  • Pill
  • Injection
Price
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Reviews
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Side effects
5possible side effects
  • Headache
    8%
  • Accidental injury
    6%
  • Flu syndrome
    5%
  • Nausea
    5%
  • Dizziness
    5%
See more detailed side effects
3possible side effects
  • Nausea
    8%
  • Vomiting
    4%
  • Upset stomach
    3%
See more detailed side effects
Risks and risk factors
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicine
    • People age 60 or older
    • Those with kidney and/or liver problems
  • Severe allergic reaction
    • History of allergy to sulfa-containing medicine
  • Breakdown of red blood cells
    • People with G6PD deficiency
  • Serious heart problems
  • Kidney and liver disease
    • Those with kidney and/or liver disease
See more detailed risks and warnings
  • Loss of medication effectiveness
  • Pancreatitis
  • Kidney problems
    • Severe renal impairment
    • End-stage renal disease
  • Serious stomach problems
    • Severe gastrointestinal disease
    • Gastroparesis
  • Low blood sugar (hypoglycemia)
See more detailed risks and warnings