Compare Amaryl vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood sugar.

Amaryl (glimepiride) is an effective medicine for lowering blood sugar, but it can cause weight gain.

Lowers your blood sugar.

Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.

3.4/ 5 average rating with 79 reviewsforJanumet
Upsides
  • Needs to be taken only once a day.
  • Effectively lowers blood sugar and A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Amaryl (glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Available as a generic form and is relatively cheap.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides
  • Amaryl (glimepiride) might cause weight gain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Not preferred for people age 65 or older because they are at higher risk of experiencing side effects such as low blood sugar.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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Reviews
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79 reviews so far
46%
saidit'sworth it
38%
saiditworked well
15%
saidit'sa big hassle

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Side effects
5possible side effects
  • Headache
    8%
  • Accidental injury
    6%
  • Flu syndrome
    5%
  • Nausea
    5%
  • Dizziness
    5%
See more detailed side effects
5possible side effects
  • Low blood sugar
    16%
  • Diarrhea
    8%
  • Upper respiratory tract infection
    6%
  • Headache
    6%
  • Abdominal pain
    2%
See more detailed side effects
Risks and risk factors
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicine
    • People age 60 or older
    • Those with kidney and/or liver problems
  • Severe allergic reaction
    • History of allergy to sulfa-containing medicine
  • Breakdown of red blood cells
    • People with G6PD deficiency
  • Serious heart problems
  • Kidney and liver disease
    • Those with kidney and/or liver disease
See more detailed risks and warnings
  • Excess lactic acid in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low vitamin B12 levels
  • Inflammation of the pancreas
  • Serious allergic reactions
See more detailed risks and warnings