Compare Amaryl vs. Lantus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Amaryl (glimepiride)

Prescription only

Lantus (insulin glargine)

Prescription only
Lowers blood sugar.

Amaryl (glimepiride) is an effective medicine for lowering blood sugar, but it can cause weight gain.

Lowers blood sugar.

Lantus (insulin glargine) is an effective, long-acting insulin that provides all-day blood sugar control, but it can cause low blood sugar levels, so be sure to have a source of sugar nearby.

3.7/ 5 average rating with 584 reviewsforLantus
Upsides
  • Needs to be taken only once a day.
  • Effectively lowers blood sugar and A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Amaryl (glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Available as a generic form and is relatively cheap.
  • Insulin is one of the most effective blood sugar-lowering medication and can lower your A1c (average blood sugar over time) by up to 2-3%.
  • Lantus (insulin glargine) is a long-lasting insulin that provides consistent, all-day sugar control with just once or twice daily dosing.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body's needs.
  • Lantus (insulin glargine) can be used with liver or kidney problems.
Downsides
  • Amaryl (glimepiride) might cause weight gain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Not preferred for people age 65 or older because they are at higher risk of experiencing side effects such as low blood sugar.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • You have to take insulin by injection.
  • You have to check your blood sugar regularly to assure your medications are working.
  • You may gain some weight, around 4-6 pounds.
  • You have to maintain a consistent schedule to avoid low blood sugar episodes. Dramatic changes in weight or meal patterns will require dose adjustments.
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Used for
Dosage forms
  • Pill
  • Injection
Price
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Reviews
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584 reviews so far
67%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

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Side effects
5possible side effects
  • Headache
    8%
  • Accidental injury
    6%
  • Flu syndrome
    5%
  • Nausea
    5%
  • Dizziness
    5%
See more detailed side effects
19possible side effects
  • Upper respiratory tract infection
    28%
  • Swelling in the limbs
    20%
  • High blood pressure
    20%
  • Flu
    19%
  • Sinus infection
    19%
  • Cataracts
    18%
  • Inflammation of the airways
    15%
  • Joint pain
    14%
  • Pain in extremity
    13%
  • Back pain
    13%
  • Cough
    12%
  • Urinary tract infection
    11%
  • Diarrhea
    11%
  • Depression
    11%
  • Infection
    10%
  • Headache
    10%
  • Blood vessel disease
    7%
  • Retinal vein disorder
    6%
  • Injection site pain
    3%
See more detailed side effects
Risks and risk factors
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicine
    • People age 60 or older
    • Those with kidney and/or liver problems
  • Severe allergic reaction
    • History of allergy to sulfa-containing medicine
  • Breakdown of red blood cells
    • People with G6PD deficiency
  • Serious heart problems
  • Kidney and liver disease
    • Those with kidney and/or liver disease
See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
  • Complications due to low potassium
    • Use of other medicine that lower potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings