Compare Amaryl vs. Precose

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Amaryl (glimepiride)

Prescription only

Precose (acarbose)

Prescription only
Lowers blood sugar.

Amaryl (glimepiride) is an effective medicine for lowering blood sugar, but it can cause weight gain.

Lowers blood sugar.

Precose (acarbose) helps lower your post-mealtime blood sugar levels, but it must be taken at the beginning of each main meal in order for it to be most effective.

Upsides
  • Needs to be taken only once a day.
  • Effectively lowers blood sugar and A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Amaryl (glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Available as a generic form and is relatively cheap.
  • Precose (acarbose) helps control meal-time blood sugar levels without causing weight gain.
  • When used alone it doesn't normally cause blood sugar levels to be too low unlike other anti-diabetes medicines.
  • Safe to be used in people age 65 or older.
  • Has relatively few interactions with other medicines.
Downsides
  • Amaryl (glimepiride) might cause weight gain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Not preferred for people age 65 or older because they are at higher risk of experiencing side effects such as low blood sugar.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • Not a first choice medicine because it isn't as effective at lowering blood sugar compared to other treatment options.
  • Associated with bothersome side effects like excessive gas and diarrhea.
  • Relatively more expensive than other diabetes medicines.
  • Has to be taken three times a day with each meal.
  • Might cause episodes of low blood sugar when taken together with insulin or medicines that stimulate insulin release.
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Dosage forms
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Reviews
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Side effects
5possible side effects
  • Headache
    8%
  • Accidental injury
    6%
  • Flu syndrome
    5%
  • Nausea
    5%
  • Dizziness
    5%
See more detailed side effects
3possible side effects
  • Excessive gas
    74%
  • Diarrhea
    31%
  • Stomach pain
    19%
See more detailed side effects
Risks and risk factors
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicine
    • People age 60 or older
    • Those with kidney and/or liver problems
  • Severe allergic reaction
    • History of allergy to sulfa-containing medicine
  • Breakdown of red blood cells
    • People with G6PD deficiency
  • Serious heart problems
  • Kidney and liver disease
    • Those with kidney and/or liver disease
See more detailed risks and warnings
  • Low blood sugar
    • Using insulin or other medicines that stimulate insulin release
  • Kidney function
    • Those with kidney problems
  • Interactions with other medicines
    • Taking multiple medicines together
See more detailed risks and warnings