Compare Amiloride vs. Inspra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps lower blood pressure and protect the heart in people with heart failure.

Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.

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  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.
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  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
Used for
  • Congestive heart failure Hypertension
  • Edema
  • Associated with thiazolidinedione use
Dosage forms
  • Pill
  • Pill
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Side effects
The Midamor (Amiloride) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • High potassium
  • Abnormal renal function
See more detailed side effects
Risks and risk factors
No information currently available
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
  • Heart problems from high potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
    • Diabetes with proteinuria
  • Breast pain or swelling
  • Kidney problems
    • Current kidney problems
  • Liver problems
    • Liver damage
See more detailed risks and warnings