Compare amoxapine vs. doxepin
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Stabilizes your mood.
While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.
Treats depression and anxiety.
doxepin can treat depression and anxiety, but it's not a first choice medication because of its many side effects.
- Asendin (amoxapine) can be used to treat more severe forms of depression.
- Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
- Asendin (amoxapine) is available as generic.
- doxepin has been consistently shown to improve symptoms of depression and anxiety.
- doxepin has been used to treat depression for over forty years.
- Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
- In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
- Not recommended in older people, children under 16, or people who've had a history of seizures.
- doxepin can make you very sleepy. Try taking it at bedtime if you need to be alert during the day.
- You shouldn't drink alcohol with doxepin. It can worsen side effects like drowsiness.
- You have to take it daily, especially if you are feeling better, for the medicine to do its job.
- It can have more side effects than other antidepressants, like weight gain and increased appetite, decreased libido, and sleepiness.
- It's not unusual for people to try different antidepressants until they find one that works for them.
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4possible side effects
- Drowsiness or fatigue14%
- Dry mouth14%
- Vision changes7%
The doxepin FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Increased risk of suicide
- People under age 24
- Vision changes
- Difficulty controlling movements
- Neuroleptic malignant syndrome
- Taking antidepressants
- Slowed breathing
- Taking opioids for pain relief or medicines for anxiety
- Anticholinergic effects/Dehydration
- Over age 65
- Suicidal thoughts or behavior
- Age 24 years or under
- Unmasking of bipolar disorder
- Bipolar disorder
- Serotonin syndrome
- Taking MAOIs (monoamine oxidase inhibitors)
- Heart problems
- History of heart disease
- Adults over 65
- Electrolyte imbalance
- Adults 65 years or older
- Taking other medicines that cause drowsiness (antihistamines, sleep medications, narcotic pain medications)
- Dizziness and falls
- Age 65 years or older