Compare amoxapine vs. Silenor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prescription only

Stabilizes your mood.

While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

Helps you relax, and sleep.

Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.

Upsides

Asendin (amoxapine) can be used to treat more severe forms of depression.
Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
Asendin (amoxapine) is available as generic.

In a clinical trial Doxepin was able to significantly improve sleep quality.
Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
Once your body gets used to Doxepin, most of the side effects go away.
Doxepin comes in a generic form, so it is pretty cheap.
Doxepin is not addictive.

Downsides

Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
Not recommended in older people, children under 16, or people who've had a history of seizures.

Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
Doxepin can increase your appetite, leading to weight gain.
Taking Doxepin can make emptying your bladder difficult.
Some people have suicidal thoughts when taking Doxepin.
Doxepin can interact with many different medications, vitamins, and alternative treatments.

Used for

Alcoholism - Anxiety - Depression Anxiety - Depression Anxiety - Depression - Psychoneurotic personality disorder Insomnia Pruritus (Moderate)
Due to atopic dermatitis or lichen simplex chronicus
Urticaria

Dosage forms