Compare Anafranil vs. Tofranil
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Helps control obsessive or compulsive behaviors.
Anafranil (clomipramine) effectively treats obsessive-compulsive disorder (OCD), but has potentially intolerable side effects.
Improves your mood and stops bedwetting in children.
Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.
Upsides
- Anafranil (clomipramine) can help with falling sleep.
- Anafranil (clomipramine) has a lower risk of causing heart problems compared to other medications like it.
- Safe to use by children.
- Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
- Available in generic.
- Tofranil (imipramine hydrochloride) is usually taken only once a day.
- Available in 3 different strengths.
Downsides
- Anafranil (clomipramine) is more likely to cause side effects than other medications for OCD.
- Anafranil (clomipramine) can affect sexual performance for men.
- It is not recommended for the elderly because it can cause fainting and falls.
- Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
- You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
- If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
Used for
Dosage forms
- Pill
- Pill
Price
Lowest price
$15.90
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$18.00
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Reviews
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Side effects
109possible side effects
- Dry mouth84%
- Sleepiness54%
- Tremor54%
- Dizziness54%
- Headache52%
- Constipation47%
- Ejaculation failure42%
- Fatigue39%
- Nausea33%
- Increased sweating28%
- Insomnia25%
- Upset stomach22%
- Loss of appetite22%
- Sex drive changes21%
- Impotence20%
- Nervousness18%
- Weight increase18%
- Abnormal vision18%
- Sore throat14%
- Urinary problems14%
- Muscle contractions13%
- Diarrhea13%
- Joint pain13%
- Abdominal pain13%
- Runny nose12%
- Menstrual cramps12%
- Increased appetite11%
- Burning/prickling skin sensation9%
- Memory problems9%
- Anxiety9%
- Sleep disorder9%
- Rash8%
- Flushing8%
- Changes in taste8%
- Twitching7%
- Vomiting7%
- Memory impairment7%
- Chest pain7%
- Allergy7%
- Weight decrease7%
- Asthma attacks7%
- Urinary retention7%
- Itching of the skin6%
- Gas6%
- Changes in blood pressure6%
- Stuffy nose6%
- Coughing6%
- Urinary tract infection6%
- Ringing in the ears6%
- Back pain6%
- Impaired concentration5%
- Depression5%
- Tooth disorder5%
- Hot flushes5%
- Increased urination5%
- Increased muscle tone4%
- Fever4%
- Palpitation4%
- Fast heartbeat4%
- Unusual milk production4%
- Menstrual disorder4%
- Pain4%
- Ear infections4%
- Changes in heartbeat4%
- Psychosomatic disorder3%
- Yawning3%
- Confusion3%
- Speech disorder3%
- Abnormal dreaming3%
- Agitation3%
- Migraine3%
- Excess tearing3%
- Social detachment2%
- Irritability2%
- Mood swings2%
- Skin irritation2%
- Acne2%
- Dry skin2%
- Gastrointestinal disorder2%
- Difficulty swallowing2%
- Local swelling2%
- Chills2%
- Nose bleed2%
- Painful urination2%
- Bladder pain2%
- Vaginal itching2%
- Increased vaginal discharge2%
- Breast enlargement2%
- Pupil dilation2%
- Thirst2%
- Muscle twitching2%
- Tingling or burning sensation2%
- Hypertonia2%
- Panic reaction2%
- Aggressive reaction2%
- Muscle weakness2%
- Abnormal skin odor2%
- Excessive burping2%
- Sores around the mouth2%
- Lack of energy2%
- Bad breath2%
- Fainting2%
- Dyspnea2%
- Laryngitis2%
- Changes in pupils2%
- Eyelid twitching2%
- Eye allergies2%
- Balance problems2%
- Anemia2%
The Tofranil (imipramine hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Antidepressants
- Lithium
- Triptans
- St. John's wort
- Fentanyl
- Tramadol
- MAO inhibitors
- Seizures
- History of seizure
- Taking other medicines that increase seizure risk
- Brain damage
- Alcoholism
- Withdrawal symptoms
- Stopping Anafranil (clomipramine) suddenly
- Low blood pressure
- Age 65 years or older
- Eye problems
- Higher risk of suicide
- Under age 24
- Possible bipolar disorder
- Heart problems
- History of heart disease
- Overactive thyroid
- Blood pressure changes
- High blood pressure
- Higher risk of seizures
- History of seizures
- Changes in metabolism
- History of diabetes