Compare Angeliq vs. Aygestin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves hot flashes and vaginal dryness due to menopause.

Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

Regulates your menstrual cycle and treats irregular bleeding.

Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.

2.7/ 5 average rating with 30 reviewsforAygestin
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
Used for
  • Pain caused by endometriosis
  • Balances hormones in women who don't have regular monthly periods
  • Balances hormones in women who have unusual monthly periods
  • In vitro fertilization
Dosage forms
  • Pill
  • Pill
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Side effects
7possible side effects
  • Stomach pain
  • Headache
  • Yeast infections
  • Breast pain
  • Nausea
  • Diarrhea
  • Swelling of arms and legs
See more detailed side effects
The Aygestin (norethindrone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Increased potassium
    • Kidney disease
    • Liver disease
    • Addison's disease
    • Medicines that cause high potassium levels
See more detailed risks and warnings
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Abnormal vision changes
  • Depression
    • History of depression
  • Changes in blood sugar levels
    • Diabetes
  • Liver problems
    • History of liver problems
  • High cholesterol levels
    • High cholesterol levels
See more detailed risks and warnings