Compare Angeliq vs. Climara Pro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves hot flashes and vaginal dryness due to menopause.

Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

Relieves hot flashes and lowers your risk of osteoporosis.

The Climara Pro (estradiol / levonorgestrel patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combination medications but prefer to use a patch once a week instead of pills every day.

Upsides
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Once-a-week patch. Good for people who don't want to take daily pills.
  • Replaces estrogen in your body and relieves multiple symptoms from low estrogen, such as hot flashes and vaginal dryness.
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The progestin in the patch protects against the risk of cancer in the uterus.
  • The Climara Pro (estradiol / levonorgestrel patch) patch has a lower risk of causing blood clots and stroke compared to other forms containing the same medicines.
Downsides
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • More potential side effects than medications with one ingredient since Climara Pro (estradiol / levonorgestrel patch) exposes your whole body to two hormones.
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can fall off, especially if you like to regularly swim, take baths, or use saunas.
  • Can be expensive since it's only available as a brand name product.
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Used for
  • Hot flashes and night sweats
  • Prevention of postmenopausal osteoporosis
Dosage forms
  • Pill
  • Patch
Price
Lowest price
$192.99
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Lowest price
$230.22
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Reviews
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Side effects
7possible side effects
  • Stomach pain
    6%
  • Headache
    6%
  • Yeast infections
    6%
  • Breast pain
    3%
  • Nausea
    3%
  • Diarrhea
    2%
  • Swelling of arms and legs
    2%
See more detailed side effects
22possible side effects
  • Skin irritation
    41%
  • Vaginal bleeding
    37%
  • Breast pain
    19%
  • Lung infection
    13%
  • Back pain
    6%
  • Depression
    6%
  • Flu like symptoms
    5%
  • Pain
    5%
  • Headache
    5%
  • Stomach pain
    4%
  • Gas
    4%
  • Swelling of arms and legs
    4%
  • Joint pain
    4%
  • Airway inflammation
    4%
  • Sinus infection
    4%
  • Accidental injury
    3%
  • Infection
    3%
  • High blood pressure
    3%
  • Weight gain
    3%
  • Bladder infection
    3%
  • Rash
    2%
  • Vaginal inflammation
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Increased potassium
    • Kidney disease
    • Liver disease
    • Addison's disease
    • Medicines that cause high potassium levels
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
Learn more about Angeliq (drospirenone / estradiol)
Learn more about Climara Pro (estradiol / levonorgestrel patch)