Compare Anzemet vs. Reglan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Anzemet (dolasetron)

Prescription only

Reglan (metoclopramide)

Prescription only
Helps prevent nausea and vomiting

Anzemet (dolasetron) prevents nausea and vomiting and does not have many side effects.

Relieves nausea and vomiting.

Reglan (metoclopramide) can stimulate your gut and relieve nausea, but it can only be used for a short period of time due to avoid serious side-effects.

Upsides
  • Reduced nausea and vomiting in people receiving chemotherapy.
  • Well-tolerated with mild headache as the most common side effect.
  • Requires only 1 dose prior to chemotherapy and once daily dosing after chemotherapy if needed for delayed nausea/vomiting.
  • Especially useful for relieving nausea caused by cancer chemotherapy.
  • Available in an affordable, generic version
  • If tablets are hard for you to swallow, Reglan (metoclopramide) is also available in as an orally disintegrating tablet or liquid form.
Downsides
  • Anzemet (dolasetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Anzemet (dolasetron) can cause problems with heart rhythm.
  • Can be expensive since a generic version is not available.
  • Use for more than 12 weeks can cause involuntary movements of the eyes, tongue, face, arm, or legs.
  • May take a while to relieve nausea and vomiting caused by delayed gastric emptying.
  • Not a good option if you have Parkinson's disease, history of seizures, or blockage in your gut.
  • You may need a lower dose if you have kidney problems.
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Used for
  • Diabetic gastroparesis
  • Gastroesophegeal reflux
  • Prevention of nausea and vomiting associated with chemotherapy
  • Prevention of postoperative nausea and vomiting
  • Radiological exam
  • Small bowel intubation
  • Gastric bezoars
  • Hiccups
  • Acute migraine
  • Treatment of nausea and vomiting in advanced cancer
  • Prevention of radiation therapy-induced nausea and vomiting
Dosage forms
  • Pill
  • Pill
  • Dissolving tablet
  • Liquid
  • Injectable
Price
No pricing information available
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Reviews
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Side effects
9possible side effects
  • Headache
    23%
  • Fatigue
    6%
  • Diarrhea
    5%
  • Decreased heart rate
    4%
  • Dizziness
    3%
  • Pain
    3%
  • Increased heart rate
    3%
  • Indigestion
    2%
  • Chills/shivering
    2%
See more detailed side effects
4possible side effects
  • Restlessness
    10%
  • Drowsiness
    10%
  • Fatigue
    10%
  • Lack of energy
    10%
See more detailed side effects
Risks and risk factors
  • Abnormal heart rhythm
    • History of heart rhythms such as long QT syndrome or atrial fibrillation
    • Heart failure
    • Taking other medications that can affect heart rhythms
    • Low potassium or magnesium levels
    • Advanced age
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels such as tramadol and anti-depressants
See more detailed risks and warnings
  • Late, irreversible, involuntary movements (tardive dyskinesia)
    • Elderly
    • Women
    • Diabetics
  • Depression
    • Depression
  • Neuroleptic malignant syndrome
  • Early, reversible involuntary movements (extrapyramidal side-effects)
    • Younger than 30 years old
    • High doses of Reglan (metoclopramide)
    • Children and teens
See more detailed risks and warnings