Compare Apokyn vs. carbidopa / levodopa extended release

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps you move around.

Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.

Treats Parkinson's disease.

Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.

Upsides
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
  • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
Downsides
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
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Used for
Dosage forms
  • Injection
  • Extended release
Price
Lowest price
$10514.49
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Reviews
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Side effects
9possible side effects
  • Yawning
    40%
  • Movement problems
    35%
  • Drowsiness or sleepiness
    35%
  • Nausea or vomiting
    30%
  • Dizziness
    20%
  • Runny nose
    20%
  • Chest pain
    15%
  • Hallucinations
    10%
  • Swelling in arms and legs
    10%
See more detailed side effects
15possible side effects
  • Difficulty controlling movements
    17%
  • Nausea
    6%
  • Hallucinations
    4%
  • Confusion
    4%
  • Dizziness
    3%
  • Depression
    2%
  • Urinary tract infection
    2%
  • Headache
    2%
  • Unusual dreams
    2%
  • Muscle spasms
    2%
  • Vomiting
    2%
  • Upper respiratory infection
    2%
  • Shortness of breath
    2%
  • Periods of immobility
    2%
  • Back pain
    2%
See more detailed side effects
Risks and risk factors
  • Fainting
  • Hallucinations
    • Taking antipsychotic medicines
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • Increased risk of heart attack or stroke
    • History of heart disease or stroke
  • Nausea and vomiting
  • Priapism
See more detailed risks and warnings
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • High fever and confusion
    • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Changes in blood pressure and falls
See more detailed risks and warnings