Compare Apriso vs. Asacol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Apriso (mesalamine)

Prescription only

Lialda (Mesalamine)

Prescription only
Maintains remission of ulcerative colitis

Apriso (mesalamine) is an effective medication for maintaining remission of ulcerative colitis that's generally well tolerated, but commonly causes headache.

Treats inflammatory bowel disease.

Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.

Upsides
  • Apriso (mesalamine) is only available as a tablet, however, mesalamine is available in different forms, including tablets, capsules, enemas, and suppositories.
  • Certain forms of Apriso (mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you have bowel inflammation.
  • It is a good option even if you have kidney or liver disease.
  • Since Apriso (mesalamine) is an extended release form, the pill is taken only once a day compared to other similar medicines and can be less irritating to the stomach and intestines.
  • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
  • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
  • Available in tablets, capsules, enemas, and suppositories.
  • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).
Downsides
  • Although you only have to take it once in the morning, you may need to take 4 capsules.
  • Apriso (mesalamine) is not available as a cheaper, generic form.
  • Should only be used if you're 18 or older.
  • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
  • Doesn't work well for severe colon inflammation.
  • You may need to take Lialda (Mesalamine) three or four times a day.
  • Not a good option if you have kidney disease.
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Used for
Dosage forms
  • Extended-release pill
  • Pill
  • Extended release
  • Enema
  • Suppository
Price
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Reviews
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Side effects
7possible side effects
  • Headache
    11%
  • Diarrhea
    8%
  • Upper stomach pain
    5%
  • Nausea
    4%
  • Common cold
    4%
  • Flu-like symptoms
    4%
  • Sinus infection
    3%
See more detailed side effects
35possible side effects
  • Headache
    35%
  • Abdominal pain
    18%
  • Eructation
    16%
  • Pain
    14%
  • Nausea
    13%
  • Pharyngitis
    11%
  • Dizziness
    8%
  • Asthenia
    7%
  • Diarrhea
    7%
  • Back pain
    7%
  • Fever
    6%
  • Rash
    6%
  • Dyspepsia
    6%
  • Rhinitis
    5%
  • Arthralgia
    5%
  • Hypertonia
    5%
  • Vomiting
    5%
  • Constipation
    5%
  • Flatulence
    3%
  • Dysmenorrhea
    3%
  • Chest pain
    3%
  • Chills
    3%
  • Flu syndrome
    3%
  • Peripheral edema
    3%
  • Myalgia
    3%
  • Sweating
    3%
  • Colitis exacerbation
    3%
  • Pruritus
    3%
  • Adverse events
    3%
  • Acne
    2%
  • Increased cough
    2%
  • Malaise
    2%
  • Arthritis
    2%
  • Conjunctivitis
    2%
  • Insomnia
    2%
See more detailed side effects
Risks and risk factors
  • Liver problems
    • Preexisting liver problems
    • Taking other medications toxic to the liver
  • Kidney problems
    • Preexisting kidney problems
    • Taking medications toxic to the kidney
  • Build up of phenylalanine in the body
    • Phenylketonuria (PKU)
  • Serious allergic reactions
    • Sulfasalazine reaction
  • Acute intolerance syndrome
See more detailed risks and warnings
  • Serious allergic reactions
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Serious allergic reactions
    • Phenylketonuria (PKU)
  • Worsening kidney or liver function
    • Kidney problems
    • Liver problems
  • Blood disorders
    • Age 65 or older
  • Liver toxicity
    • Liver problems
  • Worsening of colitis
    • Taking Lialda (Mesalamine) at the start of treatment
See more detailed risks and warnings