Compare Apriso vs. Lialda

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Apriso (mesalamine)

Prescription only

Lialda (mesalamine)

Prescription only
Maintains remission of ulcerative colitis

Apriso (mesalamine) is an effective medication for maintaining remission of ulcerative colitis that's generally well tolerated, but commonly causes headache.

Treats ulcerative colitis and helps prevent flares from coming back.

Lialda (mesalamine) effectively reduces symptoms of mild-to-moderate ulcerative colitis, and may be less irritating than other formulations, but is brand only, so may be more expensive..

Upsides
  • Apriso (mesalamine) is only available as a tablet, however, mesalamine is available in different forms, including tablets, capsules, enemas, and suppositories.
  • Certain forms of Apriso (mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you have bowel inflammation.
  • It is a good option even if you have kidney or liver disease.
  • Since Apriso (mesalamine) is an extended release form, the pill is taken only once a day compared to other similar medicines and can be less irritating to the stomach and intestines.
  • Lialda (mesalamine) effectively treats and helps maintain remission of ulcerative colitis.
  • Often used as a first-choice treatment.
  • Since Lialda (mesalamine) is a delayed release form, the pill is taken only once a day compared to other similar medicines and may be less irritating to the stomach and intestines.
  • Available as a generic.
Downsides
  • Although you only have to take it once in the morning, you may need to take 4 capsules.
  • Apriso (mesalamine) is not available as a cheaper, generic form.
  • Should only be used if you're 18 or older.
  • Treatment dosage must be taken once a day for a total of 8 weeks.
  • Can take a few weeks before you start to feel the effects.
  • Combination therapy with oral and rectal forms may be needed for some people.
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Used for
Dosage forms
  • Extended-release pill
  • Delayed-release pill
Price
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Reviews
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Side effects
7possible side effects
  • Headache
    11%
  • Diarrhea
    8%
  • Upper stomach pain
    5%
  • Nausea
    4%
  • Common cold
    4%
  • Flu-like symptoms
    4%
  • Sinus infection
    3%
See more detailed side effects
5possible side effects
  • Ulcerative colitis
    6%
  • Headache
    3%
  • Abnormal liver tests
    2%
  • Abdominal pain
    2%
  • Diarrhea
    2%
See more detailed side effects
Risks and risk factors
  • Liver problems
    • Preexisting liver problems
    • Taking other medications toxic to the liver
  • Kidney problems
    • Preexisting kidney problems
    • Taking medications toxic to the kidney
  • Build up of phenylalanine in the body
    • Phenylketonuria (PKU)
  • Serious allergic reactions
    • Sulfasalazine reaction
  • Acute intolerance syndrome
See more detailed risks and warnings
  • Kidney problems
    • Preexisting kidney problems
    • Taking medications toxic to the kidney
  • Liver problems
    • Preexisting liver problems
    • Taking other medications toxic to the liver
  • Serious allergic reactions
    • Sulfasalazine reaction
    • Allergy to salicylates (aspirin)
  • Abnormal reaction to Lialda (mesalamine)
  • Upper gastrointestinal tract blockage
  • Drug & disease precautions
See more detailed risks and warnings