Compare Arixtra vs. Pradaxa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Arixtra (fondaparinux)

Prescription only

Pradaxa (dabigatran)

Prescription only
Thins the blood and treats blood clots.

Arixtra (fondaparinux) is effective at treating clots, but it can increase your risk of bleeding.

Prevents and treats blood clots.

Pradaxa (dabigatran) is an effective oral medicine for preventing and treating blood clots, but it can increase the risk of bleeding especially in older people and those with kidney problems.

Upsides
  • Arixtra (fondaparinux) is effective at treating blood clots in the extremeties and those that have travelled to the lungs.
  • A generic form is available.
  • Arixtra (fondaparinux) is a safe option for use in patients who have experienced a rare, life-threatening reaction to another anticoagulant, heparin.
  • Pradaxa (dabigatran) doesn't require regular blood tests or frequent dose changes, unlike Coumadin.
  • Works just as well as other blood thinners in lowering the risk of stroke and heart attacks.
  • In cases of accidental overdose, an antidote is available to reverse the effects of the medicine.
  • May be taken with or without food.
Downsides
  • Arixtra (fondaparinux) should be used with caution in patients with kidney problems, as this can lead to an accumulation of the medication and increase the risk of bleeding.
  • Arixtra (fondaparinux) can cause a drop in platelet count, which can increase your risk of bleeding.
  • People who have any type of spinal or epidural procedure are more likely to have bleeding problems around the spine when taking Arixtra (fondaparinux).
  • Periodic blood tests and monitoring of your kidneys is important.
  • You have to inject yourself everyday with this medication.
  • The anti blood-clotting effects of Arixtra (fondaparinux) may remain for up to 4 days after stopping this medication in normal patients, and there is no current antidote.
  • Pradaxa (dabigatran) is not available in generic form so it can be expensive.
  • Might not be a good option for people age 75 or older and those with kidney problems due to the increased risk of bleeding.
  • Not safe to be used in people with artificial heart valves.
  • Pradaxa (dabigatran) is associated with a higher risk of stomach bleeding compared to Coumadin.
  • Might not be appropriate for people who need to take aspirin or NSAIDs (such as ibuprofen) regularly since it can add to the risk of bleeding.
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Used for
  • Treatment of blood clots
  • Revascularization following heart attack
  • Treatment of other blood clots
Dosage forms
  • Injection
  • Pill
Price
Lowest price
$3863.87
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Reviews
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Side effects
3possible side effects
  • Major bleeding
    2%
  • Bleeding index >/= 2
    2%
  • Minor bleeding
    2%
See more detailed side effects
2possible side effects
  • Any bleeding
    11%
  • Non-major bleeding
    5%
See more detailed side effects
Risks and risk factors
  • Spinal/epidural blood clots
    • Indwelling epidural catheters
    • Use of other medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) or other anticoagulants
    • History of traumatic or repeated epidural or spinal puncture
    • History of spinal surgery
  • Bleeding
    • Existing condition that increases risk of bleeding
    • Surgery
    • Use of other anticoagulants
    • Kidney problems
    • Patients with low body weight (<50kg)
    • Elderly (>75 years old)
  • Kidney problems
    • Kidney problems
  • Decreased platelet count
  • Allergic reactions
    • Latex allergy
See more detailed risks and warnings
  • Blood clots
    • Stopping Pradaxa (dabigatran) suddenly
  • Blood clots in the spine
    • People who have done a spinal tap or had a local anesthetic medicine injected into their spine
  • Increased risk of bleeding
    • Taking other medicines that also increase bleeding risk such as NSAIDs, aspirin, or blood thinners
    • People with kidney problems
    • People age 75 or older
  • People with artificial heart valves
    • People with artificial heart valve(s)
See more detailed risks and warnings