Compare Arixtra vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Arixtra (fondaparinux)

Prescription only

Xarelto (rivaroxaban)

Prescription only
Thins the blood and treats blood clots.

Arixtra (fondaparinux) is effective at treating clots, but it can increase your risk of bleeding.

Prevents blood clots.

Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.

3.5/ 5 average rating with 22 reviewsforXarelto
Upsides
  • Arixtra (fondaparinux) is effective at treating blood clots in the extremeties and those that have travelled to the lungs.
  • A generic form is available.
  • Arixtra (fondaparinux) is a safe option for use in patients who have experienced a rare, life-threatening reaction to another anticoagulant, heparin.
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Downsides
  • Arixtra (fondaparinux) should be used with caution in patients with kidney problems, as this can lead to an accumulation of the medication and increase the risk of bleeding.
  • Arixtra (fondaparinux) can cause a drop in platelet count, which can increase your risk of bleeding.
  • People who have any type of spinal or epidural procedure are more likely to have bleeding problems around the spine when taking Arixtra (fondaparinux).
  • Periodic blood tests and monitoring of your kidneys is important.
  • You have to inject yourself everyday with this medication.
  • The anti blood-clotting effects of Arixtra (fondaparinux) may remain for up to 4 days after stopping this medication in normal patients, and there is no current antidote.
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
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Used for
  • Treatment of blood clots
  • Revascularization following heart attack
  • Treatment of other blood clots
Dosage forms
  • Injection
  • Pill
Price
Lowest price
$3863.87
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Reviews
Not enough review data.Leave a review
22 reviews so far
45%
saidit'sworth it
45%
saiditworked well
9%
saidit'sa big hassle

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Side effects
3possible side effects
  • Major bleeding
    2%
  • Bleeding index >/= 2
    2%
  • Minor bleeding
    2%
See more detailed side effects
2possible side effects
  • Major bleeding needing transfusion
    4%
  • Bleeding in the stomach & intestines
    2%
See more detailed side effects
Risks and risk factors
  • Spinal/epidural blood clots
    • Indwelling epidural catheters
    • Use of other medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) or other anticoagulants
    • History of traumatic or repeated epidural or spinal puncture
    • History of spinal surgery
  • Bleeding
    • Existing condition that increases risk of bleeding
    • Surgery
    • Use of other anticoagulants
    • Kidney problems
    • Patients with low body weight (<50kg)
    • Elderly (>75 years old)
  • Kidney problems
    • Kidney problems
  • Decreased platelet count
  • Allergic reactions
    • Latex allergy
See more detailed risks and warnings
  • Blood clots and stroke
    • Stopping Xarelto (rivaroxaban) too soon
    • Artificial heart valve
  • Blood clot in the spine
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
  • Unusual bleeding
    • History of bleeding problems
    • Severe high blood pressure
    • Age 65 or older
    • Drug interactions
    • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Increased side effects
    • Current kidney problems
    • Current liver problems
See more detailed risks and warnings