Compare Artane vs. Eldepryl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats Parkinson's disease.

Artane (trihexyphenidyl) can be used to control tremors if you have Parkinson's, but it can really dry you out and cause other side effects.

Treats Parkinson's disease.

Used with other medicines for Parkinson's disease to boost its effect.

Upsides
  • Artane (trihexyphenidyl) can be used with other medicines and in people with advanced Parkinson's who still have tremors.
  • Effective by itself for people under 70 with Parkinson's who only have problems with tremors.
  • Less severe side effects compared to other medicines for tremors.
  • Available as generic.
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
Downsides
  • Not recommended in people over 65 or in people with memory problems.
  • Artane (trihexyphenidyl) only calms down tremors because of Parkinson's, but it doesn't treat other symptoms.
  • Can't be used in people with glaucoma or an enlarged prostate.
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Price
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Reviews
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Side effects
The Artane (trihexyphenidyl) FDA package insert doesn’t have numbers about how common side effects are.
11possible side effects
  • Skin irritation at the patch
    24%
  • Headache
    18%
  • Insomnia
    12%
  • Diarrhea
    9%
  • Dry mouth
    8%
  • Weight loss of at least 5%
    5%
  • Indigestion
    4%
  • Rash
    4%
  • Sore throat
    3%
  • Sinus infection
    3%
  • Weight gain of at least 5%
    2%
See more detailed side effects
Risks and risk factors
  • Neuroleptic malignant syndrome
    • Abruptly stopping Artane (trihexyphenidyl)
  • Drowsiness and dizziness
  • Vision problems
    • Narrow angle glaucoma
  • Dehydration
    • Over age 65
  • Fever and heat stroke
    • Dehydration
    • Prolonged exposure to hot conditions
    • Alcohol
    • Manual laborers
  • Psychiatric problems
    • Over age 65
    • History of mental or psychiatric problems
See more detailed risks and warnings
  • Increased blood pressure
    • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
    • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Increased risk of skin cancer
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • Low blood pressure
See more detailed risks and warnings