Compare Artane vs. Requip

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats Parkinson's disease.

Artane (trihexyphenidyl) can be used to control tremors if you have Parkinson's, but it can really dry you out and cause other side effects.

Helps with movement problems.

Requip (Ropinirole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

Upsides
  • Artane (trihexyphenidyl) can be used with other medicines and in people with advanced Parkinson's who still have tremors.
  • Effective by itself for people under 70 with Parkinson's who only have problems with tremors.
  • Less severe side effects compared to other medicines for tremors.
  • Available as generic.
  • In studies, Requip (Ropinirole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Requip (Ropinirole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
Downsides
  • Not recommended in people over 65 or in people with memory problems.
  • Artane (trihexyphenidyl) only calms down tremors because of Parkinson's, but it doesn't treat other symptoms.
  • Can't be used in people with glaucoma or an enlarged prostate.
  • Requip (Ropinirole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Requip (Ropinirole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Requip (Ropinirole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
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Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release
Price
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Reviews
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Side effects
The Artane (trihexyphenidyl) FDA package insert doesn’t have numbers about how common side effects are.
49possible side effects
  • Dyskinesia
    34%
  • Nausea
    30%
  • Dizziness
    26%
  • Adverse events
    24%
  • Somnolence
    20%
  • Headache
    17%
  • Falls
    10%
  • Hallucinations
    10%
  • Abdominal pain
    9%
  • Confusion
    9%
  • Upper respiratory tract infection
    9%
  • Hallucination
    8%
  • Increased sweating
    7%
  • Increased drug level
    7%
  • Vomiting
    7%
  • Arthralgia
    7%
  • Abdominal pain/discomfort
    6%
  • Adverse reactions
    6%
  • Tremor
    6%
  • Constipation
    6%
  • Anxiety
    6%
  • Urinary tract infection
    6%
  • Orthostatic hypotension
    5%
  • Dry mouth
    5%
  • Pain
    5%
  • Hypokinesia
    5%
  • Paresthesia
    5%
  • Diarrhea
    5%
  • Amnesia
    5%
  • Nervousness
    5%
  • Vertigo
    4%
  • Edema peripheral
    4%
  • Back pain
    3%
  • Hypertension
    3%
  • Syncope
    3%
  • Paresis
    3%
  • Arthritis
    3%
  • Abnormal dreaming
    3%
  • Dyspnea
    3%
  • Fall/injury
    2%
  • Hypotension
    2%
  • Dysphagia
    2%
  • Flatulence
    2%
  • Increased saliva
    2%
  • Weight decrease
    2%
  • Anemia
    2%
  • Pyuria
    2%
  • Urinary incontinence
    2%
  • Diplopia
    2%
See more detailed side effects
Risks and risk factors
  • Neuroleptic malignant syndrome
    • Abruptly stopping Artane (trihexyphenidyl)
  • Drowsiness and dizziness
  • Vision problems
    • Narrow angle glaucoma
  • Dehydration
    • Over age 65
  • Fever and heat stroke
    • Dehydration
    • Prolonged exposure to hot conditions
    • Alcohol
    • Manual laborers
  • Psychiatric problems
    • Over age 65
    • History of mental or psychiatric problems
See more detailed risks and warnings
  • Impulse control problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
    • Taking blood pressure-lowering medicines
  • Worsening kidney function
    • Current kidney problems
  • Skin cancer
    • Parkinson's disease
  • Hallucinations
    • Age 65 years or older
See more detailed risks and warnings