Compare Artane vs. Symmetrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats Parkinson's disease.

Artane (trihexyphenidyl) can be used to control tremors if you have Parkinson's, but it can really dry you out and cause other side effects.

Treats Parkinson's disease, the flu, and side effects from antipsychotic drugs.

Symmetrel (amantadine) is a generic medicine that can be used alone, or with other medicines to treat early Parkinson's disease.

  • Artane (trihexyphenidyl) can be used with other medicines and in people with advanced Parkinson's who still have tremors.
  • Effective by itself for people under 70 with Parkinson's who only have problems with tremors.
  • Less severe side effects compared to other medicines for tremors.
  • Available as generic.
  • Symmetrel (amantadine) can be taken by itself or with other medicines to treat the symptoms of early Parkinson's disease, including muscle spasms, tremors, and difficulty with movements.
  • Symmetrel (amantadine) is available in generic and in both a pill and liquid form.
  • Compared to other medicines for Parkinson's disease, the side effects are relatively mild.
  • Not recommended in people over 65 or in people with memory problems.
  • Artane (trihexyphenidyl) only calms down tremors because of Parkinson's, but it doesn't treat other symptoms.
  • Can't be used in people with glaucoma or an enlarged prostate.
  • Symmetrel (amantadine) sometimes has to be taken multiple times a day.
  • Symmetrel (amantadine) can’t stop or cure Parkinson's disease. It can only slow down the progression.
  • You can't take certain forms of the flu vaccine if you're taking Symmetrel (amantadine). Talk to your doctor before receiving vaccines.
  • You can't stop taking Symmetrel (amantadine) suddenly without talking to your doctor since your Parkinson's can get worse.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
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Side effects
The Artane (trihexyphenidyl) FDA package insert doesn’t have numbers about how common side effects are.
The Symmetrel (amantadine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Neuroleptic malignant syndrome
    • Abruptly stopping Artane (trihexyphenidyl)
  • Drowsiness and dizziness
  • Vision problems
    • Narrow angle glaucoma
  • Dehydration
    • Over age 65
  • Fever and heat stroke
    • Dehydration
    • Prolonged exposure to hot conditions
    • Alcohol
    • Manual laborers
  • Psychiatric problems
    • Over age 65
    • History of mental or psychiatric problems
See more detailed risks and warnings
  • Deaths from overdosage
    • Kidney damage or failure
  • Higher risk of suicide
    • Taking Symmetrel (amantadine) for the flu
  • Higher risk of seizures
    • History of seizures
  • Heart failure
    • Heart failure
    • History of swelling in the arms or legs
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
See more detailed risks and warnings