Compare aspirin vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT
Relieves pain, fever, and inflammation.

Ecotrin (aspirin) can be used for pain and fever relief or heart protection, and is generally very safe and affordable.

3.8/ 5 average rating with 533 reviewsforaspirin
Treats mild to moderate pain.

Acetaminophen with codeine (acetaminophen / codeine) is a good option to treat pain when over-the-counter medicines aren't enough, but don't take too much acetaminophen (Tylenol) since it can hurt your liver.

3.7/ 5 average rating with 581 reviewsforAcetaminophen with codeine
Upsides
  • Ecotrin (aspirin) provides the best protection for your heart to prevent heart attacks and stroke with the lowest risk of side effects
  • It is available over-the-counter in drugstores on its own and in combination with other cold and flu medications.
  • Ecotrin (aspirin) is available as a cheaper, generic form.
  • Ecotrin (aspirin) is available in several forms, including tablets, chewable tablets, and suppositories.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relief in a single pill.
  • Provides quick relief for mild to moderate pain.
  • Good for as-needed pain and control.
  • Generally well tolerated, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
Downsides
  • Ecotrin (aspirin) is not a preferred medication for treating pain, inflammation, or fever due to the high risk of bleeding.
  • Ecotrin (aspirin) increases the risk of bleeding, especially when used with other blood thinner medications like Coumadin (warfarin).
  • Dizziness and drowsiness is common, but your body may adjust.
  • Many people get constipated taking Acetaminophen with codeine (acetaminophen / codeine).
  • All opioid containing medicines have the risk of addiction and withdrawal when used long-term.
  • Acetaminophen (Tylenol) has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful since many over-the-counter medicines also have acetaminophen.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Extended release
  • Suppository
  • Pill
  • Liquid
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
533 reviews so far
76%
saidit'sworth it
41%
saiditworked well
6%
saidit'sa big hassle

Have you used Ecotrin (aspirin)?

Leave a review
581 reviews so far
69%
saidit'sworth it
41%
saiditworked well
9%
saidit'sa big hassle

Have you used Acetaminophen with codeine (acetaminophen / codeine)?

Leave a review
Side effects
The Ecotrin (aspirin) FDA package insert doesn’t have numbers about how common side effects are.
The Acetaminophen with codeine (acetaminophen / codeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Reye's Syndrome in children
    • Children 18 years or younger
    • Children recovering from viral infections
  • Bleeding
    • History of stomach bleeding or ulcers
    • Taking Ecotrin (aspirin), NSAIDs, or blood thinners
    • Alcohol use
    • People 75 years and older taking high dose (325mg) of Ecotrin (aspirin)
  • Serious allergic reactions
    • Allergy to Ecotrin (aspirin)
See more detailed risks and warnings
  • Liver failure and death
    • Alcohol use
    • Taking over-the-counter medicines with acetaminophen
    • History of liver disease
  • High risk to children
  • Use with other CNS depressants
    • Use with alcohol
    • Use with benzodiazepines
    • Use with other opiates
  • Severe allergic reaction
See more detailed risks and warnings