Compare aspirin vs. naproxen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Ecotrin (aspirin)

Prescription or OTC

Aleve (naproxen)

Prescription or OTC
Relieves pain, fever, and inflammation.

Ecotrin (aspirin) can be used for pain and fever relief or heart protection, and is generally very safe and affordable.

3.8/ 5 average rating with 533 reviewsforaspirin
Relieves pain, fever, and inflammation.

Aleve (naproxen) works well for treating mild to moderate pain or inflammation, and lasts longer than other NSAIDs.

3.9/ 5 average rating with 978 reviewsfornaproxen
Upsides
  • Ecotrin (aspirin) provides the best protection for your heart to prevent heart attacks and stroke with the lowest risk of side effects
  • It is available over-the-counter in drugstores on its own and in combination with other cold and flu medications.
  • Ecotrin (aspirin) is available as a cheaper, generic form.
  • Ecotrin (aspirin) is available in several forms, including tablets, chewable tablets, and suppositories.
  • Aleve (naproxen) is good for relieving pain from common conditions like menstrual cramps, toothaches, and arthritis.
  • It lasts longer than other NSAIDS so you don't have to take it as often.
  • Aleve (naproxen) is generally safe to use, cheap, and available over-the-counter.
  • Aleve (naproxen) causes fewer stomach problems than its alternatives.
Downsides
  • Ecotrin (aspirin) is not a preferred medication for treating pain, inflammation, or fever due to the high risk of bleeding.
  • Ecotrin (aspirin) increases the risk of bleeding, especially when used with other blood thinner medications like Coumadin (warfarin).
  • Aleve (naproxen) needs to be taken with food or millk to lower the chances of upset stomach.
  • Like all NSAIDs, Aleve (naproxen) is as not safe for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Aleve (naproxen) can raise your risk of getting blood clots, heart attack, or stroke.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Suppository
  • Pill
  • Delayed-release pill
  • Extended-release pill
  • Suspension
Price
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Reviews
533 reviews so far
76%
saidit'sworth it
41%
saiditworked well
6%
saidit'sa big hassle

Have you used Ecotrin (aspirin)?

Leave a review
978 reviews so far
78%
saidit'sworth it
48%
saiditworked well
5%
saidit'sa big hassle

Have you used Aleve (naproxen)?

Leave a review
Side effects
The Ecotrin (aspirin) FDA package insert doesn’t have numbers about how common side effects are.
The Aleve (naproxen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Reye's Syndrome in children
    • Children 18 years or younger
    • Children recovering from viral infections
  • Bleeding
    • History of stomach bleeding or ulcers
    • Taking Ecotrin (aspirin), NSAIDs, or blood thinners
    • Alcohol use
    • People 75 years and older taking high dose (325mg) of Ecotrin (aspirin)
  • Serious allergic reactions
    • Allergy to Ecotrin (aspirin)
See more detailed risks and warnings
  • Heart attack and stroke
    • History of heart problems
    • Taking the medicine for a long period of time
  • Stomach bleeding
    • History of stomach bleeding or ulcer
    • Age 60 or older
    • Taking aspirin, other NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Smoking
    • Taking the medicine for a long period of time
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings