Compare aspirin vs. Tylenol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT
Relieves pain, fever, and inflammation.

Ecotrin (aspirin) can be used for pain and fever relief or heart protection, and is generally very safe and affordable.

3.8/ 5 average rating with 533 reviewsforaspirin
Relieves pain and fever.

Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.

3.7/ 5 average rating with 1002 reviewsforTylenol
Upsides
  • Ecotrin (aspirin) provides the best protection for your heart to prevent heart attacks and stroke with the lowest risk of side effects
  • It is available over-the-counter in drugstores on its own and in combination with other cold and flu medications.
  • Ecotrin (aspirin) is available as a cheaper, generic form.
  • Ecotrin (aspirin) is available in several forms, including tablets, chewable tablets, and suppositories.
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
Downsides
  • Ecotrin (aspirin) is not a preferred medication for treating pain, inflammation, or fever due to the high risk of bleeding.
  • Ecotrin (aspirin) increases the risk of bleeding, especially when used with other blood thinner medications like Coumadin (warfarin).
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Extended release
  • Suppository
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
Price
No pricing information available
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
533 reviews so far
76%
saidit'sworth it
41%
saiditworked well
6%
saidit'sa big hassle

Have you used Ecotrin (aspirin)?

Leave a review
1002 reviews so far
77%
saidit'sworth it
37%
saiditworked well
3%
saidit'sa big hassle

Have you used Tylenol Regular Strength (acetaminophen)?

Leave a review
Side effects
The Ecotrin (aspirin) FDA package insert doesn’t have numbers about how common side effects are.
The Tylenol Regular Strength (acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Reye's Syndrome in children
    • Children 18 years or younger
    • Children recovering from viral infections
  • Bleeding
    • History of stomach bleeding or ulcers
    • Taking Ecotrin (aspirin), NSAIDs, or blood thinners
    • Alcohol use
    • People 75 years and older taking high dose (325mg) of Ecotrin (aspirin)
  • Serious allergic reactions
    • Allergy to Ecotrin (aspirin)
See more detailed risks and warnings
  • Accidental overdose and death
    • Medication administering errors
    • Injection formulation
    • Exceeding the recommended maximum daily limits
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
See more detailed risks and warnings