Compare Astepro vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Astepro (azelastine)

Prescription only

Zyrtec (Cetirizine)

Prescription or OTC
Relieves nasal allergy symptoms.

Astepro (azelastine) is an antihistamine nasal spray that can help with allergy or nasal symptoms.

Treats allergy symptoms.

Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.

3.8/ 5 average rating with 1232 reviewsforZyrtec
Upsides
  • Astepro (azelastine) is good for relieving nasal symptoms during allergy season.
  • Since Astepro (azelastine) goes in the nose, it's unlikely you'll get side effects anywhere else in your body.
  • Astepro (azelastine) works faster than steroid nasal sprays and can be used as needed.
  • People usually tolerate Astepro (azelastine) well since there are few side effects.
  • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (Cetirizine) is available over the counter without a prescription.
  • It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It's okay to take with most other medications because it has few drug interactions.
  • Most people don't get any side effects from Zyrtec (Cetirizine).
Downsides
  • Astepro (azelastine) has 200 sprays, but no counter to help keep track of sprays.
  • It can cause a bitter taste in your mouth.
  • Although it works fast, its effectiveness wears off for some people over time.
  • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
  • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
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Used for
Dosage forms
  • Nasal spray
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
No pricing information available
No pricing information available
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Reviews
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1232 reviews so far
76%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

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Side effects
5possible side effects
  • Bitter Taste
    8%
  • Nose discomfort
    4%
  • Nosebleeds
    2%
  • Headache
    2%
  • Fatigue
    2%
See more detailed side effects
The Zyrtec (Cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Difficulty concentrating
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Taking the wrong medication
  • Increased side effects
    • Age 65 or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Overdosage
    • Current kidney disease
    • Current liver disease
See more detailed risks and warnings