Compare Astepro vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Astepro (azelastine)

Prescription only

Zyrtec (cetirizine)

Over-the-counter
Relieves nasal allergy symptoms.

Astepro (azelastine) is an antihistamine nasal spray that can help with allergy or nasal symptoms.

Treats allergy symptoms.

Zyrtec (cetirizine) can help you with some allergy symptoms without making you very drowsy.

3.8/ 5 average rating with 1232 reviewsforZyrtec
Upsides
  • Astepro (azelastine) is good for relieving nasal symptoms during allergy season.
  • Since Astepro (azelastine) goes in the nose, it's unlikely you'll get side effects anywhere else in your body.
  • Astepro (azelastine) works faster than steroid nasal sprays and can be used as needed.
  • People usually tolerate Astepro (azelastine) well since there are few side effects.
  • Zyrtec (cetirizine) works to treat sneezing and runny nose, and causes less sedation compared to Benadryl.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (cetirizine) is available over the counter without a prescription. It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide relief of allergy symptoms for both kids and adults.
  • Zyrtec (cetirizine) has few drug interactions with other medicines.
  • Most people don't get any side effects from Zyrtec (cetirizine).
Downsides
  • Astepro (azelastine) has 200 sprays, but no counter to help keep track of sprays.
  • It can cause a bitter taste in your mouth.
  • Although it works fast, Zyrtec (cetirizine)'s effectiveness wears off for some people over time.
  • Zyrtec (cetirizine) can make you a little more sleepy compared to Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl (diphenhydramine), are more effective for them than Zyrtec (cetirizine).
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Used for
Dosage forms
  • Nasal spray
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
Price
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Reviews
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1232 reviews so far
76%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

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Side effects
5possible side effects
  • Bitter Taste
    8%
  • Nose discomfort
    4%
  • Nosebleeds
    2%
  • Headache
    2%
  • Fatigue
    2%
See more detailed side effects
The Zyrtec (cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Difficulty concentrating
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Increased side effects in the elderly
    • Age 65 or older
  • Impaired alertness
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • History of liver or kidney conditions
    • History of liver or kidney disease
See more detailed risks and warnings