Compare Atripla vs. Odefsey
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats HIV infection.
Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.
Treats HIV infection
Odefsey (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It's similar to Complera, but contains a newer HIV drug which has shown to cause less harmful effects on your kidneys and bones.
Upsides
- Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
- Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
- There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
- Odefsey (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
- Odefsey (emtricitabine / rilpivirine / tenofovir) is currently the smallest combination HIV tablet available.
- Odefsey (emtricitabine / rilpivirine / tenofovir) works similar to Complera, but is less likely to cause harmful side effects on your kidneys and bones.
- Odefsey (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
Downsides
- Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
- Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
- Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
- Odefsey (emtricitabine / rilpivirine / tenofovir) has to be taken with a light meal.
- Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need an acid reducer, try taking an antacid like calcium carbonate either 2 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir).
- Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
- Can cause abnormal heart rhythm.
Used for
Dosage forms
- Pill
- Pill
Price
Lowest price
$2979.94
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$3435.97
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Reviews
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Side effects
13possible side effects
- Diarrhea9%
- Nausea9%
- Fatigue9%
- Depression9%
- Sinusitis8%
- Upper respiratory tract infections8%
- Dizziness8%
- Rash Event7%
- Headache6%
- Nasopharyngitis5%
- Anxiety5%
- Insomnia5%
- Vomiting2%
8possible side effects
- Headache19%
- Depression19%
- Somnolence14%
- Nausea11%
- Dizziness8%
- Abdominal pain8%
- Vomiting6%
- Rash6%
Risks and risk factors
- Lactic acidosis | Enlarged, fatty liver
- Liver disease
- Women
- Obesity
- Cannot be used to treat Hepatitis B Virus (HBV)
- Hepatitis B Virus infection
- Mood and behavior changes
- History of mental health problems
- History of drug abuse
- Liver damage
- History of liver disease
- Taking alcohol or other drugs that can damage the liver.
- Bone loss/osteoporosis
- History of bone fractures
- Osteoporosis
- Kidney damage
- History of kidney damage
- Taking other medicines that can harm the kidneys
- Lactic acidosis | Enlarged, fatty liver
- Liver disease
- Women
- Obesity
- Worsening hepatitis B infection
- Hepatitis B Virus infection
- Mood and behavior changes
- History of mental health problems
- Bone loss/osteoporosis
- History of bone fractures
- Osteoporosis
- Kidney damage
- History of kidney damage
- Taking other medicines that can harm the kidneys
- Allergic reactions
- Prior severe allergic reaction to Odefsey (emtricitabine / rilpivirine / tenofovir) or any of its individual drug components.