Compare Aygestin vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Aygestin (norethindrone)

Prescription only

Prometrium (Progesterone)

Prescription only
Regulates your menstrual cycle and treats irregular bleeding.

Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.

2.7/ 5 average rating with 30 reviewsforAygestin
Taken for irregular bleeding or paired with estrogen replacements for menopause.

Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.

3.4/ 5 average rating with 64 reviewsforPrometrium
Upsides
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
Downsides
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
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Used for
  • Pain caused by endometriosis
  • Balances hormones in women who don't have regular monthly periods
  • Balances hormones in women who have unusual monthly periods
  • In vitro fertilization
Dosage forms
  • Pill
  • Pill
  • Injection
Price
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Reviews
30 reviews so far
40%
saidit'sworth it
23%
saiditworked well
23%
saidit'sa big hassle

Have you used Aygestin (norethindrone)?

Leave a review
64 reviews so far
61%
saidit'sworth it
41%
saiditworked well
17%
saidit'sa big hassle

Have you used Prometrium (Progesterone)?

Leave a review
Side effects
The Aygestin (norethindrone) FDA package insert doesn’t have numbers about how common side effects are.
The Prometrium (Progesterone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Abnormal vision changes
  • Depression
    • History of depression
  • Changes in blood sugar levels
    • Diabetes
  • Liver problems
    • History of liver problems
  • High cholesterol levels
    • High cholesterol levels
See more detailed risks and warnings
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Severe allergic reactions
    • Allergy to peanuts
  • Fluid retention (Foot and leg swelling)
    • Heart failure
    • Kidney problems
    • Obesity
  • Depression
    • History of depression
See more detailed risks and warnings