Compare AzaSite vs. Zylet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats pink eye.

AzaSite (azithromycin) effectively treats pink eye and requires you to place less drops into your eye compared to similar medications, but it can be expensive.

Treats certain eye inflammation and infections.

Zylet (loteprednol and tobramycin) is a good choice for certain eye infections and conditions, but isn't for everyone and you can't use it for a long time.

  • Less frequent applications make AzaSite (azithromycin) more convenient to use than similar medicines.
  • Since you apply AzaSite (azithromycin) directly to the eye(s), there are minimal systemic side effects.
  • Zylet (loteprednol and tobramycin) is very effective at reducing inflammation and treating infection in certain eye conditions.
  • Since Zylet (loteprednol and tobramycin) is applied directly into the eye, you won't experience any severe body side effects.
  • AzaSite (azithromycin) is not available as a generic and costs significantly more than similar medicines.
  • Directly applying AzaSite (azithromycin) to the eyes can irritate them.
  • Zylet (loteprednol and tobramycin) is expensive.
  • Taking Zylet (loteprednol and tobramycin) can be burdensome, as you have to use it multiple times a day.
  • There's a limit to how much Zylet (loteprednol and tobramycin) can be used.
Used for
  • Steroid responsive eye inflammation conditions
  • Superficial eye infections
  • Blepharitis
Dosage forms
  • Eye drops
  • Eye drops
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Side effects
1possible side effects
  • Eye irritation
See more detailed side effects
12possible side effects
  • Headache
  • Increased eye pressures
  • Eye burning
  • Eye stinging
  • Vision problems
  • Eye discharge
  • Eye itching
  • Tearing problems
  • Light sensitivity
  • Eye deposits
  • Eyelid problems
  • Other non-specific eye disorders
See more detailed side effects
Risks and risk factors
  • Allergy to ingredients
    • Allergies to systemic azithromycin.
  • Risk for eye infection
  • Not to be used with contact lenses
  • For use topically in the eyes only
  • New infection
    • Prolonged use
See more detailed risks and warnings
  • Increased eye pressure
    • Taking Zylet (loteprednol and tobramycin) with other steroids
  • Cataracts
  • Delayed healing
    • Recent cataract surgery
    • Cornea problems
  • Second infections
    • Acute purulent eye infections
  • Allergic reaction
See more detailed risks and warnings